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    Sult1c2 sulfotransferase family 1C member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171072, updated on 3-Apr-2024

    Summary

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    Symbol
    Sult1c2provided by RGD
    Full Name
    sulfotransferase family 1C member 2provided by RGD
    Primary source
    RGD:621064
    See related
    Ensembl:ENSRNOG00000065530 AllianceGenome:RGD:621064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ST1C2; sultK1; rSULT1C2
    Summary
    Enables aryl sulfotransferase activity. Involved in sulfation. Located in lysosome. Orthologous to human SULT1C2 (sulfotransferase family 1C member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Restricted expression toward (RPKM 2818.1) See more
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    Genomic context

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    See Sult1c2 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (7436981..7486894)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6824840..6848830)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4654278..4685418, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase 1C2A-like Neighboring gene putative sperm motility kinase W Neighboring gene sulfotransferase family 1C member 2A like 1 Neighboring gene sulfotransferase family 1C member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. Rondini EA, et al. J Pharmacol Exp Ther, 2015 Dec. PMID 26427720, Free PMC Article
    2. Decreased sulfotransferase SULT1C2 gene expression in DPT-induced polycystic kidney. Sugimura K, et al. Kidney Int, 2002 Sep. PMID 12164856
    3. Enzymatic properties, tissue-specific expression, and lysosomal location of two highly homologous rat SULT1C2 sulfotransferases. Xiangrong L, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872834
    4. Expression of the sulfotransferase 1C family: implications for xenobiotic toxicity. Runge-Morris M, et al. Drug Metab Rev, 2013 Nov. PMID 24028175
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our findings demonstrate that cholesterol biosynthetic intermediates influence SULT1C2 expression in rat primary
      Title: Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112625, MGC124969

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1C2
    Names
    sulfotransferase 1C2-like
    sulfotransferase K1
    sulfotransferase family, cytosolic, 1C, member 2
    NP_598231.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133547.6 → NP_598231.4  sulfotransferase 1C2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JUM0, A0A8I6ARK1
      Conserved Domains (1) summary
      pfam00685
      Location:39 → 288
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      7436981..7486894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUW8.2 GenPept UniProtKB/Swiss-Prot:Q9WUW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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