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    Foxn3 forkhead box N3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314374, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Foxn3provided by RGD
    Official Full Name
    forkhead box N3provided by RGD
    Primary source
    RGD:1305711
    See related
    Ensembl:ENSRNOG00000004709 AllianceGenome:RGD:1305711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ches1
    Summary
    Predicted to enable DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Predicted to be involved in mitotic G2 DNA damage checkpoint signaling and negative regulation of transcription, DNA-templated. Predicted to act upstream of or within craniofacial suture morphogenesis. Predicted to be active in nucleus. Orthologous to human FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 129.3), Heart (RPKM 84.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Foxn3 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (124191695..124572070, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (118462018..118842442, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (123183720..123577719, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479466 Neighboring gene uncharacterized LOC134479465 Neighboring gene uncharacterized LOC102550790 Neighboring gene uncharacterized LOC102550560 Neighboring gene uncharacterized LOC108351290 Neighboring gene EF-hand calcium binding domain 11 Neighboring gene uncharacterized LOC120103598

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. Scott KL, et al. Gene, 2005 Oct 10. PMID 16102918
    2. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Pati D, et al. Mol Cell Biol, 1997 Jun. PMID 9154802, Free PMC Article
    3. Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. Busygina V, et al. Cancer Res, 2006 Sep 1. PMID 16951149
    4. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Samaan G, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20691664
    5. FOXN3 Regulates Hepatic Glucose Utilization. Karanth S, et al. Cell Rep, 2016 Jun 21. PMID 27292639, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within craniofacial suture morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein N3
    Names
    checkpoint suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108047.2 → NP_001101517.1  forkhead box protein N3

      See identical proteins and their annotated locations for NP_001101517.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JEF9, D3ZIJ7
      Related
      ENSRNOP00000006604.4, ENSRNOT00000006604.7
      Conserved Domains (1) summary
      pfam00250
      Location:114 → 201
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      124191695..124572070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764802.4 → XP_008763024.1  forkhead box protein N3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYT8
      Related
      ENSRNOP00000070786.1
      Conserved Domains (1) summary
      pfam00250
      Location:114 → 201
      Forkhead; Forkhead domain

    2. XM_017594165.3 → XP_017449654.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    3. XM_017594166.3 → XP_017449655.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    4. XM_063261969.1 → XP_063118039.1  forkhead box protein N3 isoform X3

      UniProtKB/TrEMBL
      A6JEF9, D3ZIJ7

    5. XM_039112337.2 → XP_038968265.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    6. XM_039112340.2 → XP_038968268.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    7. XM_008764801.4 → XP_008763023.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_008763023.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    8. XM_039112336.2 → XP_038968264.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    9. XM_039112342.2 → XP_038968270.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    10. XM_039112341.2 → XP_038968269.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    11. XM_063261970.1 → XP_063118040.1  forkhead box protein N3 isoform X3

      UniProtKB/TrEMBL
      A6JEF9, D3ZIJ7

    12. XM_063261967.1 → XP_063118037.1  forkhead box protein N3 isoform X3

      UniProtKB/TrEMBL
      A6JEF9, D3ZIJ7

    13. XM_006240429.5 → XP_006240491.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_006240491.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    14. XM_063261968.1 → XP_063118038.1  forkhead box protein N3 isoform X3

      UniProtKB/TrEMBL
      A6JEF9, D3ZIJ7

    15. XM_039112339.2 → XP_038968267.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    16. XM_006240431.5 → XP_006240493.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_006240493.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    17. XM_063261971.1 → XP_063118041.1  forkhead box protein N3 isoform X3

      UniProtKB/TrEMBL
      A6JEF9, D3ZIJ7

    18. XM_039112343.2 → XP_038968271.1  forkhead box protein N3 isoform X4

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)
    Nucleotide Protein Strain
    Heading Accession and Version

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