Pon1 paraoxonase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pon1provided by RGD
Official Full Name: paraoxonase 1provided by RGD
Primary source: RGD:620062
See related: AllianceGenome:RGD:620062
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables aryldialkylphosphatase activity. Involved in several processes, including response to fatty acid; response to fluoride; and response to nutrient levels. Located in extracellular space and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 6153.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (34261312..34292327, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (33294737..33325759, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (30249749..30276297, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.
Title: BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.
Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo.
Title: Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo.
resveratrol exhibits an effect on attenuating the retinal inflammatory condition and damage of DR via PON1. Our study suggests that resveratrol-induced PON1 in the retina may be a promising therapeutic strategy to prevent diabetes-related retinopathy.
Title: Resveratrol exhibits an effect on attenuating retina inflammatory condition and damage of diabetic retinopathy via PON1.
Study indicates that low PON1 expression is predictive of severe IVDD; PON1 plays an important role of keeping the homeostatic balance of intervertebral discs.
Title: Paraoxonase 1 Was Negatively Associated With Intervertebral Disc Degeneration.
results indicate that PON1 functions as a novel regulator of T cell development.
Title: Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage.
18beta-GA has a protective effect on MTX-induced nephrotoxicity with possible mechanisms of attenuating oxidative stress and inflammation through up-regulating the Nrf2/ARE signaling
Title: 18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
Compared with the rats in the control group, the serum activity of xanthine oxidase was significantly higher and that of PON1 was significantly lower in the rats in the model nonalcoholic fatty liver disease group (P<0.01).
Title: Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.
Acai extract increased serum PON1 activity and reduced hepatic steatosis and hepatic injury in rats fed a high fat diet.
Title: Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats.
investigated the changes in plasma PON1 activity, LDL oxidation, radical scavenging activity and lipid peroxidation in D-galactose-induced aging model and also compared the results with 24-month naturally aged rats
Title: Plasma paraoxonase 1 arylesterase activity in D-galactose-induced aged rat model: correlation with LDL oxidation and redox status.
Study documented, for the first time, the presence of PON3 in rat serum and, notably, found that the upregulation of PON3, rather than PON1, appears to be associated with physical training.
Title: Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

U32684 (e-PCR)
- UniSTS:125724

RH127354 (e-PCR)
- UniSTS:210664

RH140838 (e-PCR)
- UniSTS:210664

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity	IEA Inferred from Electronic Annotation more info
enables aryldialkylphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryldialkylphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryldialkylphosphatase activity	IEA Inferred from Electronic Annotation more info
enables aryldialkylphosphatase activity	ISO Inferred from Sequence Orthology more info
enables aryldialkylphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylesterase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables arylesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aromatic compound catabolic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic compound catabolic process	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in negative regulation of plasma lipoprotein oxidation	ISO Inferred from Sequence Orthology more info
involved_in organophosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in organophosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluoride	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serum paraoxonase/arylesterase 1

Names: A-esterase 1; PON 1; aromatic esterase 1; serum aryldialkylphosphatase 1

NP_114466.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

XP_038964390.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.