Ctdnep1 CTD nuclear envelope phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctdnep1provided by RGD
Official Full Name: CTD nuclear envelope phosphatase 1provided by RGD
Primary source: RGD:1310172
See related: Ensembl:ENSRNOG00000017352 AllianceGenome:RGD:1310172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dullard
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Predicted to act upstream of or within gamete generation; mesoderm development; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 174.6), Spleen (RPKM 98.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55203047..55212469)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54704367..54713781)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56590822..56600235)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamete generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamete generation	ISO Inferred from Sequence Orthology more info
involved_in mesoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Nem1-Spo7 phosphatase complex	IEA Inferred from Electronic Annotation more info
part_of Nem1-Spo7 phosphatase complex	ISO Inferred from Sequence Orthology more info
part_of Nem1-Spo7 phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CTD nuclear envelope phosphatase 1

Names: serine/threonine-protein phosphatase dullard

NP_001093964.1

EC 3.1.3.16

XP_006246705.2

EC 3.1.3.16

XP_006246706.2

EC 3.1.3.16

XP_063124715.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100494.1 → NP_001093964.1 CTD nuclear envelope phosphatase 1

See identical proteins and their annotated locations for NP_001093964.1

Status: VALIDATED

Source sequence(s)

BC107474, BU671232

UniProtKB/Swiss-Prot

Q3B7T6, Q5M952

UniProtKB/TrEMBL

A0A8L2QCF2, A6HFZ4

Related

ENSRNOP00000023379.5, ENSRNOT00000023379.5

Conserved Domains (1) summary

TIGR02251
Location:61 → 229

HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55203047..55212469

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268645.1 → XP_063124715.1 CTD nuclear envelope phosphatase 1 isoform X3
XM_006246643.5 → XP_006246705.2 CTD nuclear envelope phosphatase 1 isoform X1

UniProtKB/TrEMBL

A0A8L2QCF2

Conserved Domains (1) summary

TIGR02251
Location:93 → 265

HIF-SF_euk; Dullard-like phosphatase domain
XM_006246644.5 → XP_006246706.2 CTD nuclear envelope phosphatase 1 isoform X2

UniProtKB/TrEMBL

A0A8I6GLT1, A0A8L2QCF2

Related

ENSRNOP00000096868.1

Conserved Domains (1) summary

TIGR02251
Location:93 → 261

HIF-SF_euk; Dullard-like phosphatase domain