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    Cmip c-Maf-inducing protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292051, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cmipprovided by RGD
    Official Full Name
    c-Maf-inducing proteinprovided by RGD
    Primary source
    RGD:1306101
    See related
    Ensembl:ENSRNOG00000013178 AllianceGenome:RGD:1306101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    c-Mip; RGD1306101
    Summary
    Predicted to act upstream of or within in utero embryonic development. Predicted to be active in cytosol and nucleoplasm. Orthologous to human CMIP (c-Maf inducing protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 69.5), Kidney (RPKM 61.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmip in Genome Data Viewer
    Location:
    19q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (62213402..62419443)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (45304597..45510653)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (49792273..50000535)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene gigaxonin Neighboring gene transfer RNA serine (anticodon AGA) 23 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated like 1 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene uncharacterized LOC102548350 Neighboring gene uncharacterized LOC120098622 Neighboring gene phospholipase C, gamma 2 Neighboring gene uncharacterized LOC120098492 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization. Yu L, et al. Mol Med Rep, 2017 Oct. PMID 28791377
    2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CMIP inhibits cofilin1 activity and alters podocyte cytoskeleton organization at least through RhoA signaling in PAinduced podocyte injury
      Title: c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-Maf-inducing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163273.1 → NP_001156745.1  C-Maf-inducing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2JYB9, A0A8I6A9M1
      Related
      ENSRNOP00000087879.1, ENSRNOT00000112862.1
      Conserved Domains (3) summary
      cd09293
      Location:594 → 768
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:664 → 687
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00169
      Location:71 → 157
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      62213402..62419443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277945.1 → XP_063134015.1  C-Maf-inducing protein isoform X1

      UniProtKB/TrEMBL
      A6IZH3

    2. XM_006255684.5 → XP_006255746.1  C-Maf-inducing protein isoform X2

      See identical proteins and their annotated locations for XP_006255746.1

      UniProtKB/TrEMBL
      F1M8D3
      Conserved Domains (2) summary
      cd09293
      Location:476 → 615
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:511 → 534
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_039097643.2 → XP_038953571.1  C-Maf-inducing protein isoform X3

      UniProtKB/TrEMBL
      F1M8D3
      Conserved Domains (2) summary
      cd09293
      Location:442 → 581
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:477 → 500
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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