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    Map4k1 mitogen activated protein kinase kinase kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292763, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Map4k1provided by RGD
    Official Full Name
    mitogen activated protein kinase kinase kinase kinase 1provided by RGD
    Primary source
    RGD:1305463
    See related
    Ensembl:ENSRNOG00000020505 AllianceGenome:RGD:1305463
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hpk1
    Summary
    Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Used to study transient cerebral ischemia. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 137.9), Thymus (RPKM 92.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q21
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93398460..93419996)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84270951..84292496)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87937126..87959514)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene calpain 12 Neighboring gene actinin alpha 4 Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene ryanodine receptor 1 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene family with sequence similarity 98, member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression. Li T, et al. Neuroreport, 2008 Apr 16. PMID 18382279
    2. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region. Li T, et al. FEBS Lett, 2008 Jun 11. PMID 18498770
    3. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Hu MC, et al. Genes Dev, 1996 Sep 15. PMID 8824585
    4. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. Leung IW, et al. J Biol Chem, 2001 Jan 19. PMID 11053428
    5. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. Kiefer F, et al. EMBO J, 1996 Dec 16. PMID 9003777, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tyrosine phosphorylation of HPK1 promotes ischemic brain injury by activated Src via N-methyl-d-aspartate receptor and, ultimately, the activation of the MLK3-MKK7-JNK3 pathway after cerebral ischemia.
      Title: Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region.
    2. knockdown of hematopietic progenitor kinase 1 expression provides neuroprotection
      Title: Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to phorbol 13-acetate 12-myristate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 1
    Names
    hematopoietic progenitor kinase 1
    NP_001099713.1
    XP_006228778.1
    XP_008757344.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106243.1 → NP_001099713.1  mitogen-activated protein kinase kinase kinase kinase 1

      See identical proteins and their annotated locations for NP_001099713.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A0A8I6A6A3, A6J9M5, D3Z8I4
      Related
      ENSRNOP00000027837.4, ENSRNOT00000027837.7
      Conserved Domains (3) summary
      smart00036
      Location:506 → 813
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:17 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16 → 274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93398460..93419996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228716.5 → XP_006228778.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6A3
      Conserved Domains (3) summary
      smart00036
      Location:506 → 812
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:17 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16 → 274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    2. XM_008759122.4 → XP_008757344.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6A3
      Conserved Domains (3) summary
      smart00220
      Location:17 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16 → 274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
      cl02434
      Location:517 → 767
      CNH; CNH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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