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    Cox18 cytochrome c oxidase assembly factor COX18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289522, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cox18provided by RGD
    Official Full Name
    cytochrome c oxidase assembly factor COX18provided by RGD
    Primary source
    RGD:1559547
    See related
    Ensembl:ENSRNOG00000003052 AllianceGenome:RGD:1559547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559547
    Summary
    Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly; protein insertion into mitochondrial inner membrane from matrix; and protein insertion into mitochondrial membrane. Predicted to be integral component of mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 29.2), Adrenal (RPKM 28.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (18147558..18161622)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17864581..17877483)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (19434728..19446379)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L8, pseudogene 4 Neighboring gene ankyrin repeat domain 17 Neighboring gene uncharacterized LOC134481729 Neighboring gene uncharacterized LOC134481731 Neighboring gene uncharacterized LOC134481730 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly. Sacconi S, et al. Biochem Biophys Res Commun, 2005 Nov 25. PMID 16212937
    2. The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast. Gaisne M, et al. FEMS Yeast Res, 2006 Sep. PMID 16911509
    3. Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module. Bourens M, et al. J Biol Chem, 2017 May 12. PMID 28330871, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane insertase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory chain complex IV assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial inner membrane protein COX18
    Names
    COX18 cytochrome c oxidase assembly homolog
    COX18, cytochrome c oxidase assembly factor
    cytochrome c oxidase assembly homolog 18
    cytochrome c oxidase assembly protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106000.1 → NP_001099470.1  mitochondrial inner membrane protein COX18

      See identical proteins and their annotated locations for NP_001099470.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474060
      UniProtKB/TrEMBL
      A6KKG4, A6KKG5
      Conserved Domains (1) summary
      cl00489
      Location:76 → 296
      60KD_IMP; 60Kd inner membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      18147558..18161622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250771.5 → XP_006250833.1  mitochondrial inner membrane protein COX18 isoform X1

      UniProtKB/TrEMBL
      A6KKG5, D4A568
      Related
      ENSRNOP00000004074.5
      Conserved Domains (1) summary
      cd20069
      Location:76 → 297
      5TM_Oxa1-like; Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins

    2. XM_006250772.5 → XP_006250834.1  mitochondrial inner membrane protein COX18 isoform X2

      Conserved Domains (1) summary
      cl00489
      Location:76 → 187
      60KD_IMP; 60Kd inner membrane protein

    RNA

    1. XR_005492906.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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