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    Zfp523 zinc finger protein 523 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361809, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Zfp523provided by RGD
    Official Full Name
    zinc finger protein 523provided by RGD
    Primary source
    RGD:1306239
    See related
    Ensembl:ENSRNOG00000000501 AllianceGenome:RGD:1306239
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf76
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF76 (zinc finger protein 76). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 55.1), Adrenal (RPKM 52.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp523 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6234951..6268258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6234884..6266512)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7750786..7786020)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349039 Neighboring gene uncharacterized LOC120098860 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3 Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene peroxisome proliferator-activated receptor delta Neighboring gene uncharacterized LOC120098961

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins. Kubota H, et al. J Biol Chem, 2000 Sep 15. PMID 10893243
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188390

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 76
    Names
    zinc finger protein 76 (expressed in testis)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134755.1 → NP_001128227.1  zinc finger protein 76

      See identical proteins and their annotated locations for NP_001128227.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168249
      UniProtKB/Swiss-Prot
      B4F7E9
      UniProtKB/TrEMBL
      A0A0G2K9C3
      Related
      ENSRNOP00000000595.6, ENSRNOT00000000595.7
      Conserved Domains (4) summary
      COG5048
      Location:192 → 257
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:212 → 238
      zf-H2C2_2; Zinc-finger double domain
      pfam17017
      Location:225 → 346
      zf-C2H2_aberr; Aberrant zinc-finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6234951..6268258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279220.1 → XP_063135290.1  zinc finger protein 76 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9C3

    2. XM_008772820.4 → XP_008771042.1  zinc finger protein 76 isoform X1

      See identical proteins and their annotated locations for XP_008771042.1

      UniProtKB/TrEMBL
      A0A0G2K9C3
      Conserved Domains (2) summary
      COG5048
      Location:179 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_039098817.2 → XP_038954745.1  zinc finger protein 76 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9C3
      Conserved Domains (2) summary
      COG5048
      Location:179 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_039098818.2 → XP_038954746.1  zinc finger protein 76 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:170 → 310
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_063279222.1 → XP_063135292.1  zinc finger protein 76 isoform X4

    6. XM_063279221.1 → XP_063135291.1  zinc finger protein 76 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4F7E9.1 GenPept UniProtKB/Swiss-Prot:B4F7E9

    Gene LinkOut

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