Thrap3 thyroid hormone receptor associated protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thrap3provided by RGD
Official Full Name: thyroid hormone receptor associated protein 3provided by RGD
Primary source: RGD:1306129
See related: Ensembl:ENSRNOG00000009977 AllianceGenome:RGD:1306129
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including phosphoprotein binding activity; thyroid hormone receptor binding activity; and transcription coactivator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Predicted to act upstream of or within circadian rhythm. Predicted to be located in nuclear speck. Predicted to be part of mediator complex. Orthologous to human THRAP3 (thyroid hormone receptor associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 409.0), Spleen (RPKM 333.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (143729821..143772105, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (138445284..138487544, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (144178248..144221318, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of exon-exon junction complex	IEA Inferred from Electronic Annotation more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISS Inferred from Sequence or Structural Similarity more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: thyroid hormone receptor-associated protein 3

Names: thyroid hormone receptor-associated protein complex 150 kDa component; trap150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009693.1 → NP_001009693.1 thyroid hormone receptor-associated protein 3

See identical proteins and their annotated locations for NP_001009693.1

Status: PROVISIONAL

Source sequence(s)

BC088415

UniProtKB/Swiss-Prot

Q5M7V8

UniProtKB/TrEMBL

A0A8I5ZUG9

Related

ENSRNOP00000013570.5, ENSRNOT00000013570.7

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

143729821..143772105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238867.4 → XP_006238929.1 thyroid hormone receptor-associated protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUG9, A0A8I6A105

Related

ENSRNOP00000085793.1

Conserved Domains (1) summary

pfam15440
Location:343 → 595

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_039110014.2 → XP_038965942.1 thyroid hormone receptor-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5M7V8

UniProtKB/TrEMBL

A0A8I5ZUG9

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_039110015.2 → XP_038965943.1 thyroid hormone receptor-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5M7V8

UniProtKB/TrEMBL

A0A8I5ZUG9

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_008764021.4 → XP_008762243.1 thyroid hormone receptor-associated protein 3 isoform X1

See identical proteins and their annotated locations for XP_008762243.1

UniProtKB/Swiss-Prot

Q5M7V8

UniProtKB/TrEMBL

A0A8I5ZUG9

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_063287755.1 → XP_063143825.1 thyroid hormone receptor-associated protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I6A105
XM_008764022.4 → XP_008762244.1 thyroid hormone receptor-associated protein 3 isoform X1

See identical proteins and their annotated locations for XP_008762244.1

UniProtKB/Swiss-Prot

Q5M7V8

UniProtKB/TrEMBL

A0A8I5ZUG9

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_063287753.1 → XP_063143823.1 thyroid hormone receptor-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5M7V8
XM_063287754.1 → XP_063143824.1 thyroid hormone receptor-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5M7V8
XM_039110018.2 → XP_038965946.1 thyroid hormone receptor-associated protein 3 isoform X4

Conserved Domains (1) summary

pfam15440
Location:3 → 484

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_063287756.1 → XP_063143826.1 thyroid hormone receptor-associated protein 3 isoform X5
XM_039110017.2 → XP_038965945.1 thyroid hormone receptor-associated protein 3 isoform X3

Conserved Domains (1) summary

pfam15440
Location:191 → 704

THRAP3_BCLAF1; THRAP3/BCLAF1 family