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    Rpl6 ribosomal protein L6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117042, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rpl6provided by RGD
    Official Full Name
    ribosomal protein L6provided by RGD
    Primary source
    RGD:619826
    See related
    Ensembl:ENSRNOG00000025936 AllianceGenome:RGD:619826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 5.8S rRNA binding activity; mRNA binding activity; and tRNA binding activity. Predicted to be involved in cytoplasmic translation and ribosomal large subunit assembly. Located in A band. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 3663.1), Thymus (RPKM 3203.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41008142..41012756, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35347493..35352011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40877578..40882032, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S20-like Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene uncharacterized LOC134481334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Separate binding sites on rat liver ribosomal protein L6 for 5 S and 5.8 S ribosomal ribonucleic acids and for transfer ribonucleic acids. Ulbrich N, et al. J Biol Chem, 1982 Oct 10. PMID 7118887
    2. The primary structure of rat ribosomal protein L6. Chan YL, et al. Biochem Mol Biol Int, 1996 Jun. PMID 8828793
    3. Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues. Ohta K, et al. J Mol Endocrinol, 1994 Feb. PMID 8185817
    4. Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1979 Sep 10. PMID 468846
    5. Ribosomal proteins cross-linked to natural mRNA by UV irradiation of rat liver polysomes. Takahashi Y, et al. J Biochem, 1981 Nov. PMID 7338522

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93267

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5.8S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL6
    Names
    60S ribosomal protein L6
    neoplasm-related protein C140

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053971.3 → NP_446423.2  large ribosomal subunit protein eL6

      See identical proteins and their annotated locations for NP_446423.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097295
      UniProtKB/Swiss-Prot
      P21533, Q4QRA9, Q64624, Q68G26
      UniProtKB/TrEMBL
      A6J1G1, Q6P790
      Conserved Domains (2) summary
      cd13156
      Location:146 → 298
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:51 → 105
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41008142..41012756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249378.5 → XP_006249440.1  large ribosomal subunit protein eL6 isoform X2

      See identical proteins and their annotated locations for XP_006249440.1

      UniProtKB/Swiss-Prot
      P21533, Q4QRA9, Q64624, Q68G26
      UniProtKB/TrEMBL
      A6J1G1, Q6P790
      Conserved Domains (2) summary
      cd13156
      Location:146 → 298
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:51 → 105
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    2. XM_039089033.2 → XP_038944961.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QIW0
      Related
      ENSRNOP00000038065.6
      Conserved Domains (2) summary
      cd13156
      Location:153 → 305
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:58 → 112
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    3. XM_039089034.2 → XP_038944962.1  large ribosomal subunit protein eL6 isoform X2

      UniProtKB/Swiss-Prot
      P21533, Q4QRA9, Q64624, Q68G26
      UniProtKB/TrEMBL
      A6J1G1, Q6P790
      Conserved Domains (2) summary
      cd13156
      Location:146 → 298
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:51 → 105
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21533.5 GenPept UniProtKB/Swiss-Prot:P21533

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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