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    Rab28 RAB28, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117049, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Rab28provided by RGD
    Official Full Name
    RAB28, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:620891
    See related
    Ensembl:ENSRNOG00000017074 AllianceGenome:RGD:620891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTP binding activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within toxin transport. Located in ciliary basal body and ciliary rootlet. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 170.7), Heart (RPKM 161.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab28 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (73458386..73535367)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (69245846..69322968)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (73888968..73963209)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550431 Neighboring gene uncharacterized LOC120096626 Neighboring gene RNA polymerase III subunit F, pseudogene 1 Neighboring gene clusterin associated protein 1, pseudogene 2 Neighboring gene developmental pluripotency-associated protein 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy. Roosing S, et al. Am J Hum Genet, 2013 Jul 11. PMID 23746546, Free PMC Article
    2. Involvement of Rab28 in NF-κB nuclear transport in endothelial cells. Jiang J, et al. PLoS One, 2013. PMID 23457503, Free PMC Article
    3. Large nucleotide-dependent conformational change in Rab28. Lee SH, et al. FEBS Lett, 2008 Dec 10. PMID 19026641, Free PMC Article
    4. Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini. Brauers A, et al. Eur J Biochem, 1996 May 1. PMID 8647132
    5. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab28 is novel regulator of NFkB nuclear transport in endothelial cells.
      Title: Involvement of Rab28 in NF-κB nuclear transport in endothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-28
    Names
    rab-26
    NP_446430.1
    XP_008768417.1
    XP_008768418.1
    XP_008768419.1
    XP_008768420.1
    XP_017454543.1
    XP_063128875.1
    XP_063128876.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053978.1 → NP_446430.1  ras-related protein Rab-28

      See identical proteins and their annotated locations for NP_446430.1

      Status: PROVISIONAL

      Source sequence(s)
      X78606
      UniProtKB/Swiss-Prot
      P51158
      UniProtKB/TrEMBL
      A6IJR0, A6IJR3
      Related
      ENSRNOP00000071725.1, ENSRNOT00000081033.2
      Conserved Domains (1) summary
      cd04109
      Location:13 → 221
      Rab28; Rab GTPase family 28 (Rab28)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      73458386..73535367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770196.3 → XP_008768418.1  ras-related protein Rab-28 isoform X1

      See identical proteins and their annotated locations for XP_008768418.1

      UniProtKB/TrEMBL
      A6IJR0, Q6IN03
      Conserved Domains (1) summary
      cd04109
      Location:13 → 220
      Rab28; Rab GTPase family 28 (Rab28)

    2. XM_017599054.3 → XP_017454543.1  ras-related protein Rab-28 isoform X5

      UniProtKB/TrEMBL
      A6IJR0, A6IJR1
      Conserved Domains (2) summary
      smart00175
      Location:13 → 178
      RAB; Rab subfamily of small GTPases
      cl21455
      Location:13 → 191
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_008770198.3 → XP_008768420.1  ras-related protein Rab-28 isoform X4

      See identical proteins and their annotated locations for XP_008768420.1

      UniProtKB/TrEMBL
      A0A8I5ZQN9, A6IJQ9, A6IJR0
      Related
      ENSRNOP00000080796.1
      Conserved Domains (1) summary
      cl38936
      Location:13 → 193
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_008770195.3 → XP_008768417.1  ras-related protein Rab-28 isoform X1

      See identical proteins and their annotated locations for XP_008768417.1

      UniProtKB/TrEMBL
      A6IJR0, Q6IN03
      Related
      ENSRNOP00000050260.2
      Conserved Domains (1) summary
      cd04109
      Location:13 → 220
      Rab28; Rab GTPase family 28 (Rab28)

    5. XM_063272805.1 → XP_063128875.1  ras-related protein Rab-28 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GGV5

    6. XM_008770197.4 → XP_008768419.1  ras-related protein Rab-28 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GGV5
      Conserved Domains (2) summary
      smart00175
      Location:16 → 170
      RAB; Rab subfamily of small GTPases
      cd04109
      Location:16 → 213
      Rab28; Rab GTPase family 28 (Rab28)

    7. XM_063272806.1 → XP_063128876.1  ras-related protein Rab-28 isoform X6

      UniProtKB/TrEMBL
      A6IJR0

    RNA

    1. XR_005492875.2 RNA Sequence

    2. XR_005492878.2 RNA Sequence

    3. XR_005492874.2 RNA Sequence

    4. XR_005492877.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51158.1 GenPept UniProtKB/Swiss-Prot:P51158

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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