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    Nme3 NME/NM23 nucleoside diphosphate kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85269, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nme3provided by RGD
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 3provided by RGD
    Primary source
    RGD:619879
    See related
    Ensembl:ENSRNOG00000015749 AllianceGenome:RGD:619879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NM23-dr
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in nucleotide metabolic process. Orthologous to human NME3 (NME/NM23 nucleoside diphosphate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 168.1), Kidney (RPKM 148.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nme3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14421922..14422878)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13917309..13918415)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14258232..14259365)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene uncharacterized LOC134480762 Neighboring gene Jupiter microtubule associated homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis. Negroni A, et al. Cell Death Differ, 2000 Sep. PMID 11042679
    2. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, et al. J Bioenerg Biomembr, 2000 Jun. PMID 11768308
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate kinase 3
    Names
    expressed in non-metastatic cells 3, protein (nucleoside diphosphate kinase)
    non-metastatic cell expressed protein 3
    non-metastatic cells 3, protein expressed in
    NP_445959.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053507.1 → NP_445959.1  nucleoside diphosphate kinase 3 precursor

      See identical proteins and their annotated locations for NP_445959.1

      Status: PROVISIONAL

      Source sequence(s)
      AY017337
      UniProtKB/TrEMBL
      A6HCY6, G3V816, Q99NI1
      Related
      ENSRNOP00000021650.1, ENSRNOT00000021650.3
      Conserved Domains (2) summary
      cd04413
      Location:22 → 151
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:22 → 156
      NDK; Nucleoside diphosphate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14421922..14422878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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