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    Uchl3 ubiquitin C-terminal hydrolase L3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498560, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Uchl3provided by RGD
    Official Full Name
    ubiquitin C-terminal hydrolase L3provided by RGD
    Primary source
    RGD:1561196
    See related
    Ensembl:ENSRNOG00000009530 AllianceGenome:RGD:1561196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UCH-L3; RGD1561196
    Summary
    Predicted to enable thiol-dependent deubiquitinase and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of fat cell differentiation; and protein deubiquitination. Predicted to act upstream of or within adult walking behavior; eating behavior; and retina development in camera-type eye. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 143.0), Thymus (RPKM 92.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uchl3 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (84888847..84942095)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (78485304..78527355)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (86153624..86198127)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 4 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X, pseudogene 1 Neighboring gene COMM domain containing 6 Neighboring gene HCLS1 associated protein X-1, pseudogene 3 Neighboring gene uncharacterized LOC134482002 Neighboring gene LIM domain 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis. Suzuki M, et al. Endocrinology, 2009 Dec. PMID 19837878
    2. Ubiquitin dimers control the hydrolase activity of UCH-L3. Setsuie R, et al. Neurochem Int, 2009 May-Jun. PMID 19154770
    3. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Kurihara LJ, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555633
    4. Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). Dennissen FJ, et al. FEBS Lett, 2011 Aug 19. PMID 21762696
    5. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Larsen CN, et al. Biochemistry, 1998 Mar 10. PMID 9521656

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L3
    Names
    ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
    ubiquitin thioesterase L3
    NP_001103635.1
    XP_038949527.1
    XP_063130639.1
    XP_063130640.1
    XP_063130641.1
    XP_063130642.1
    XP_063130643.1
    XP_063130644.1
    XP_063130645.1
    XP_063130646.1
    XP_063130647.1
    XP_063130648.1
    XP_063130649.1
    XP_063130650.1
    XP_063130651.1
    XP_063130652.1
    XP_063130653.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110165.2 → NP_001103635.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

      See identical proteins and their annotated locations for NP_001103635.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q91Y78
      UniProtKB/TrEMBL
      A6KKZ2, D4ABI6, F1LM67
      Related
      ENSRNOP00000012842.5, ENSRNOT00000012842.7
      Conserved Domains (1) summary
      cd09616
      Location:6 → 227
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    2. NM_001428945.1 → NP_001415874.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    3. NM_001428946.1 → NP_001415875.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    4. NM_001428947.1 → NP_001415876.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      84888847..84942095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274573.1 → XP_063130643.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X5

    2. XM_063274569.1 → XP_063130639.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

    3. XM_063274578.1 → XP_063130648.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X10

    4. XM_039093599.2 → XP_038949527.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X15

      UniProtKB/TrEMBL
      A0A8I6AE48, D4ABI6, F1LM67
      Related
      ENSRNOP00000091247.1
      Conserved Domains (1) summary
      cd09616
      Location:6 → 211
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    5. XM_063274577.1 → XP_063130647.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X9

    6. XM_063274579.1 → XP_063130649.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X11

      UniProtKB/TrEMBL
      A0A8J8Y1V7

    7. XM_063274572.1 → XP_063130642.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X4

    8. XM_063274574.1 → XP_063130644.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X6

    9. XM_063274570.1 → XP_063130640.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2

    10. XM_063274582.1 → XP_063130652.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X14

    11. XM_063274581.1 → XP_063130651.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X13

      UniProtKB/TrEMBL
      A6HU77

    12. XM_063274580.1 → XP_063130650.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X12

    13. XM_063274576.1 → XP_063130646.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X8

    14. XM_063274583.1 → XP_063130653.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X16

    15. XM_063274571.1 → XP_063130641.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3

    16. XM_063274575.1 → XP_063130645.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y78.1 GenPept UniProtKB/Swiss-Prot:Q91Y78

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