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    N4bp2 NEDD4 binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305342, updated on 6-Jun-2024

    Summary

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    Official Symbol
    N4bp2provided by RGD
    Official Full Name
    NEDD4 binding protein 2provided by RGD
    Primary source
    RGD:1565738
    See related
    Ensembl:ENSRNOG00000027152 AllianceGenome:RGD:1565738
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565738
    Summary
    Predicted to enable ATP binding activity; endonuclease activity; and polydeoxyribonucleotide 5'-hydroxyl-kinase activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis and phosphorylation. Predicted to be located in cytosol. Orthologous to human N4BP2 (NEDD4 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 102.6), Liver (RPKM 83.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See N4bp2 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42696415..42819535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42342690..42479861, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43963353..44092844, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic alpha 9 subunit Neighboring gene HAUS augmin-like complex, subunit 8, pseudogene 3 Neighboring gene ras homolog family member H Neighboring gene U6 spliceosomal RNA Neighboring gene PDS5 cohesin associated factor A Neighboring gene ribosomal protein L14 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310
    2. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. Watanabe N, et al. J Biol Chem, 2003 Jul 11. PMID 12730195
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      42696415..42819535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092735.2 → XP_038948663.1  NEDD4-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4H4, A0A8I6GHF3
      Related
      ENSRNOP00000034526.6
      Conserved Domains (4) summary
      smart00463
      Location:1677 → 1759
      SMR; Small MutS-related domain
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1610 → 1671
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:455 → 581
      AAA_33; AAA domain

    2. XM_017599466.3 → XP_017454955.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4H4
      Conserved Domains (3) summary
      smart00463
      Location:1597 → 1679
      SMR; Small MutS-related domain
      pfam08590
      Location:1530 → 1591
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:375 → 501
      AAA_33; AAA domain

    3. XM_039092734.2 → XP_038948662.1  NEDD4-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4H4, A0A8I6GHF3
      Conserved Domains (4) summary
      smart00463
      Location:1677 → 1759
      SMR; Small MutS-related domain
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1610 → 1671
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:455 → 581
      AAA_33; AAA domain

    4. XM_017599459.3 → XP_017454948.1  NEDD4-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4H4, A0A8I6GHF3
      Related
      ENSRNOP00000088789.1
      Conserved Domains (4) summary
      smart00463
      Location:1677 → 1759
      SMR; Small MutS-related domain
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1610 → 1671
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:455 → 581
      AAA_33; AAA domain

    5. XM_039092736.2 → XP_038948664.1  NEDD4-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4H4, A0A8I6GHF3
      Conserved Domains (4) summary
      smart00463
      Location:1677 → 1759
      SMR; Small MutS-related domain
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1610 → 1671
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:455 → 581
      AAA_33; AAA domain

    6. XM_017599463.3 → XP_017454952.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4H4
      Conserved Domains (3) summary
      smart00463
      Location:1597 → 1679
      SMR; Small MutS-related domain
      pfam08590
      Location:1530 → 1591
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:375 → 501
      AAA_33; AAA domain

    7. XM_017599465.3 → XP_017454954.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4H4
      Conserved Domains (3) summary
      smart00463
      Location:1597 → 1679
      SMR; Small MutS-related domain
      pfam08590
      Location:1530 → 1591
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:375 → 501
      AAA_33; AAA domain

    8. XM_063273824.1 → XP_063129894.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4H4

    9. XM_063273823.1 → XP_063129893.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4H4

    10. XM_039092740.2 → XP_038948668.1  NEDD4-binding protein 2 isoform X3

      Conserved Domains (2) summary
      smart00463
      Location:1149 → 1231
      SMR; Small MutS-related domain
      pfam08590
      Location:1082 → 1143
      DUF1771; Domain of unknown function (DUF1771)
    Nucleotide Protein Strain
    Heading Accession and Version

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