Gp2 glycoprotein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gp2provided by RGD
Official Full Name: glycoprotein 2provided by RGD
Primary source: RGD:621695
See related: Ensembl:ENSRNOG00000015716 AllianceGenome:RGD:621695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: gp80
Summary: Predicted to enable antigen binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in neutrophil migration. Predicted to act upstream of or within antigen transcytosis by M cells in mucosal-associated lymphoid tissue. Located in zymogen granule membrane. Is anchored component of external side of plasma membrane. Orthologous to human GP2 (glycoprotein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 903.6), Kidney (RPKM 323.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183228395..183243954, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (173797057..173812619, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189166735..189182306, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GP2 undergoes sequential intracellular cleavage during secretion.
Title: Processing of the major pancreatic zymogen granule membrane protein, GP2.
Thus, GP2 expression in AR4-2J cells does not affect amylase packaging in secretory granules or stimulated secretion. GP2 expression also does not influence membrane recycling in response to stimulated stimulation in AR4-2J cells.
Title: Effects of GP2 expression on secretion and endocytosis in pancreatic AR4-2J cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antigen binding	IEA Inferred from Electronic Annotation more info
enables antigen binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen transcytosis by M cells in mucosal-associated lymphoid tissue	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in neutrophil migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pancreatic secretory granule membrane major glycoprotein GP2

Names: glycoprotein 2 (zymogen granule membrane); glycoprotein 80; pancreatic zymogen granule membrane protein GP-2; secretory (zymogen) granule membrane glycoprotein GP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134418.3 → NP_599245.2 pancreatic secretory granule membrane major glycoprotein GP2 precursor

See identical proteins and their annotated locations for NP_599245.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P19218

UniProtKB/TrEMBL

A6I8K7

Related

ENSRNOP00000021249.3, ENSRNOT00000021249.3

Conserved Domains (2) summary

smart00241
Location:225 → 476

ZP; Zona pellucida (ZP) domain

pfam00100
Location:354 → 474

Zona_pellucida; Zona pellucida-like domain