Vipr2 vasoactive intestinal peptide receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vipr2provided by RGD
Official Full Name: vasoactive intestinal peptide receptor 2provided by RGD
Primary source: RGD:3962
See related: Ensembl:ENSRNOG00000004317 AllianceGenome:RGD:3962
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables vasoactive intestinal polypeptide receptor activity. Involved in activation of adenylate cyclase activity and negative regulation of smooth muscle cell proliferation. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in schizophrenia 16. Orthologous to human VIPR2 (vasoactive intestinal peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 29.3), Thymus (RPKM 27.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q33

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (143139672..143213609)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (136996664..137070599)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (143932960..144009476)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic beta cells.
Title: VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells.
PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
the protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with repetitive applications of chemical dural stimulations.
Title: Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats.
In cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional; VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation.
Title: Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.
Although cerebellar arteries expressed transcripts for all three PACAP receptor subtypes, middle meningeal arteries demonstrated only PAC1 and VPAC2 receptor expression.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) potently dilates middle meningeal arteries: implications for migraine.
both VPAC1 and VPAC2 could have roles at all stages of retinal development, that PACAP acts through a specific set of PAC1 isoforms, and that Hip and Hop1 are predominantly involved in the postnatal development of rat retina.
Title: Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina.
Expression and distribution of vasoactive intestinal peptide receptor 2 remains unchanged in aged rat brains.
Title: Region-specific changes in the immunoreactivity of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC2, and PAC1 receptor) in the aged rat brains.
investigation of role of VPAC2 (& VPAC1) in pulmonary circulation in health/disease: distribution of VPAC2 (& VPAC1) in aorta/pulmonary artery (& smooth muscle cells); effects of VPAC antagonists on cell proliferation; dominant role of VPAC2
Title: Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation.
Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
Title: Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
inhibitory effect of pituitary adenylate cyclase-activating polypeptide on food intake may be mediated, at least in part, through modulation of neuropeptide Y neurotransmission
Title: Expression of PACAP receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139640 (e-PCR)
- UniSTS:221724

AA818985 (e-PCR)
- UniSTS:249735

RH132714 (e-PCR)
- UniSTS:215997

UniSTS:224723 (e-PCR)
- UniSTS:224723

Vipr2 (e-PCR), detects polymorphism
- UniSTS:546543

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables vasoactive intestinal polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasoactive intestinal polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vasoactive intestinal polypeptide receptor 2

Names: PACAP type III receptor; PACAP-R-3; PACAP-R3; VIP-R-2; pituitary adenylate cyclase-activating polypeptide type III receptor; vasopressive intestinal peptide receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017238.2 → NP_058934.2 vasoactive intestinal polypeptide receptor 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P35000

UniProtKB/TrEMBL

A6KDK7

Related

ENSRNOP00000005876.5, ENSRNOT00000005876.5

Conserved Domains (2) summary

smart00008
Location:47 → 117

HormR; Domain present in hormone receptors

cd15986
Location:122 → 390

7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

143139672..143213609

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594055.3 → XP_017449544.1 vasoactive intestinal polypeptide receptor 2 isoform X1
XM_063261586.1 → XP_063117656.1 vasoactive intestinal polypeptide receptor 2 isoform X1
XM_039111853.2 → XP_038967781.1 vasoactive intestinal polypeptide receptor 2 isoform X5

Conserved Domains (1) summary

smart00008
Location:47 → 117

HormR; Domain present in hormone receptors
XM_039111850.2 → XP_038967778.1 vasoactive intestinal polypeptide receptor 2 isoform X2

Conserved Domains (3) summary

smart00008
Location:47 → 117

HormR; Domain present in hormone receptors

cd14964
Location:276 → 303

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:247 → 345

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039111852.2 → XP_038967780.1 vasoactive intestinal polypeptide receptor 2 isoform X4

Conserved Domains (1) summary

smart00008
Location:47 → 117

HormR; Domain present in hormone receptors
XM_039111851.2 → XP_038967779.1 vasoactive intestinal polypeptide receptor 2 isoform X3

Conserved Domains (2) summary

cd14964
Location:20 → 42

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:13 → 252

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily