Adora1 adenosine A1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adora1provided by RGD
Official Full Name: adenosine A1 receptorprovided by RGD
Primary source: RGD:2048
See related: Ensembl:ENSRNOG00000003442 AllianceGenome:RGD:2048
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including lipid homeostasis; modulation of chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axon; basolateral plasma membrane; and synaptic membrane. Is active in calyx of Held. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 184.0), Spleen (RPKM 61.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48210922..48247826, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45658872..45695821, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51042111..51076913, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of adenosine A1 receptor potentiates metabotropic glutamate receptor 1-mediated Ca[2+] mobilization in the rat hippocampal marginal zone.
Title: Activation of adenosine A(1) receptor potentiates metabotropic glutamate receptor 1-mediated Ca(2+) mobilization in the rat hippocampal marginal zone.
Activation of the adenosine A1 receptor in the lumbosacral spinal cord improves bladder overactivity in rats with cystitis induced by cyclophosphamide.
Title: Activation of the adenosine A1 receptor in the lumbosacral spinal cord improves bladder overactivity in rats with cystitis induced by cyclophosphamide.
A1 and A2b adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro.
Title: A(1) and A(2b) adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro.
Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
Title: Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke.
Title: In vivo multimodal imaging of adenosine A(1) receptors in neuroinflammation after experimental stroke.
Role of spinal adenosine A1 receptors in the analgesic effect of electroacupuncture in a rat model of neuropathic pain.
Title: Role of spinal adenosine A1 receptors in the analgesic effect of electroacupuncture in a rat model of neuropathic pain.
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Title: Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Hyperthermia-induced seizures produce long-term effects on the functionality of adenosine A1 receptor in rat cerebral cortex.
Title: Hyperthermia-induced seizures produce long-term effects on the functionality of adenosine A(1) receptor in rat cerebral cortex.
Based on these results, we suggest that XNJI promotes arousal by inhibiting adenosine neurotransmission via reducing adenosine level and the expression of A1R and ENT1.
Title: Effects of Xingnaojing Injection on Adenosinergic Transmission and Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma Rats.
corticotropin-releasing factor (CRF) and alpha1 adrenergic receptor (alpha1AR) signaling enhance the plasticity of NMDA-receptor-mediated glutamatergic transmission in ventral tegmental area.
Title: Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning.

Submit: New GeneRIF Correction See all GeneRIFs (134)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Hmgc03 (e-PCR)
- UniSTS:518941

BB176431 (e-PCR)
- UniSTS:185452

Adora1 (e-PCR), detects polymorphism
- UniSTS:256460

UniSTS:141040 (e-PCR)
- UniSTS:141040

Adora1 (e-PCR), detects polymorphism
- UniSTS:141040

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled adenosine receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-protein beta/gamma-subunit complex binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables heterotrimeric G-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables purine nucleoside binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
acts_upstream_of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurotrophin production	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in negative regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of respiratory gaseous exchange by nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	EXP Inferred from Experiment more info	PubMed
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenosine receptor A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429640.1 → NP_001416569.1 adenosine receptor A1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429641.1 → NP_001416570.1 adenosine receptor A1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429642.1 → NP_001416571.1 adenosine receptor A1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429643.1 → NP_001416572.1 adenosine receptor A1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429644.1 → NP_001416573.1 adenosine receptor A1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429645.1 → NP_001416574.1 adenosine receptor A1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_017155.4 → NP_058851.2 adenosine receptor A1

See identical proteins and their annotated locations for NP_058851.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P25099

UniProtKB/TrEMBL

A6ICB1, O08766

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

48210922..48247826 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090620.2 → XP_038946548.1 adenosine receptor A1 isoform X2

Conserved Domains (2) summary

cd14964
Location:35 → 65

7tm_GPCRs; TM helix 5 [structural motif]

cl28897
Location:1 → 157

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039090618.2 → XP_038946546.1 adenosine receptor A1 isoform X1

UniProtKB/Swiss-Prot

P25099

UniProtKB/TrEMBL

A6ICB1, O08766

Related

ENSRNOP00000004602.1

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006249859.5 → XP_006249921.1 adenosine receptor A1 isoform X1

UniProtKB/Swiss-Prot

P25099

UniProtKB/TrEMBL

A6ICB1, O08766

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063272203.1 → XP_063128273.1 adenosine receptor A1 isoform X1

UniProtKB/Swiss-Prot

P25099

UniProtKB/TrEMBL

A6ICB1
XM_039090619.2 → XP_038946547.1 adenosine receptor A1 isoform X1

UniProtKB/Swiss-Prot

P25099

UniProtKB/TrEMBL

A6ICB1, O08766

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039090617.2 → XP_038946545.1 adenosine receptor A1 isoform X1

UniProtKB/Swiss-Prot

P25099

UniProtKB/TrEMBL

A6ICB1, O08766

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors