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    Prcd photoreceptor disc component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912216, updated on 8-Mar-2024

    Summary

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    Symbol
    Prcdprovided by RGD
    Full Name
    photoreceptor disc componentprovided by RGD
    Primary source
    RGD:6488422
    See related
    AllianceGenome:RGD:6488422
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable opsin binding activity. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 36. Orthologous to human PRCD (photoreceptor disc component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 24.7), Adrenal (RPKM 8.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prcd in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102386025..102406485)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101887192..101907647)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105630686..105642427)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene aralkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2 Neighboring gene cytoglobin Neighboring gene small nucleolar RNA R38 Neighboring gene uncharacterized LOC108352161 Neighboring gene small nucleolar RNA, C/D box 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The progressive rod-cone degeneration (PRCD) protein is secreted through the conventional ER/Golgi-dependent pathway. Remez L, et al. Exp Eye Res, 2014 Aug. PMID 24992209
    2. Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability. Spencer WJ, et al. Biochemistry, 2016 Sep 13. PMID 27509380, Free PMC Article
    3. Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration. Skiba NP, et al. J Proteome Res, 2013 Jun 7. PMID 23672200, Free PMC Article
    4. Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. Murphy J, et al. J Biol Chem, 2016 Oct 28. PMID 27613864, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables opsin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    photoreceptor disc component; photoreceptor disk component PRCD
    Names
    progressive rod-cone degeneration

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102386025..102406485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597748.3 → XP_017453237.1  photoreceptor disk component PRCD isoform X1

      Conserved Domains (1) summary
      pfam15201
      Location:1 → 52
      Rod_cone_degen; Progressive rod-cone degeneration

    2. XM_017597749.3 → XP_017453238.1  photoreceptor disk component PRCD isoform X2

      Conserved Domains (1) summary
      pfam15201
      Location:1 → 45
      Rod_cone_degen; Progressive rod-cone degeneration

    3. XM_039087485.2 → XP_038943413.1  photoreceptor disk component PRCD isoform X1

      Conserved Domains (1) summary
      pfam15201
      Location:1 → 52
      Rod_cone_degen; Progressive rod-cone degeneration

    4. XM_039087481.2 → XP_038943409.1  photoreceptor disk component PRCD isoform X1

      Conserved Domains (1) summary
      pfam15201
      Location:1 → 52
      Rod_cone_degen; Progressive rod-cone degeneration

    RNA

    1. XR_005490549.2 RNA Sequence

    2. XR_010055480.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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