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    Rasgef1b RasGEF domain family, member 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361238, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rasgef1bprovided by RGD
    Official Full Name
    RasGEF domain family, member 1Bprovided by RGD
    Primary source
    RGD:1562220
    See related
    Ensembl:ENSRNOG00000002345 AllianceGenome:RGD:1562220
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562220
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 130.1), Kidney (RPKM 109.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (10164366..10684184)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9859512..10380044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11499692..12028513)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096568 Neighboring gene uncharacterized LOC134481713 Neighboring gene uncharacterized LOC108352713 Neighboring gene uncharacterized LOC134481715 Neighboring gene eukaryotic translation elongation factor 2, pseudogene 3 Neighboring gene uncharacterized LOC134481714 Neighboring gene uncharacterized LOC120096569 Neighboring gene uncharacterized LOC120096570 Neighboring gene PRELI domain containing 1, pseudogene 4 Neighboring gene uncharacterized LOC134481716 Neighboring gene protein kinase cGMP-dependent 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. Yaman E, et al. FEBS J, 2009 Aug. PMID 19645719
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-GEF domain-containing family member 1B
    Names
    GPIgamma4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      10164366..10684184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599428.3 → XP_017454917.1  ras-GEF domain-containing family member 1B isoform X2

      UniProtKB/TrEMBL
      D3ZJN7

    2. XM_017599427.3 → XP_017454916.1  ras-GEF domain-containing family member 1B isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKE8, D3ZJN7
      Related
      ENSRNOP00000093715.1

    3. XM_017599429.3 → XP_017454918.1  ras-GEF domain-containing family member 1B isoform X3

      UniProtKB/TrEMBL
      D3ZJN7

    4. XM_063273740.1 → XP_063129810.1  ras-GEF domain-containing family member 1B isoform X4

    5. XM_002728083.7 → XP_002728129.2  ras-GEF domain-containing family member 1B isoform X5

      UniProtKB/TrEMBL
      D3ZJN7
      Related
      ENSRNOP00000003207.7
      Conserved Domains (2) summary
      cd06224
      Location:42 → 167
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:205 → 454
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    Nucleotide Protein Strain
    Heading Accession and Version

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