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    Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497932, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Pik3r6provided by RGD
    Official Full Name
    phosphoinositide-3-kinase, regulatory subunit 6provided by RGD
    Primary source
    RGD:1560850
    See related
    Ensembl:ENSRNOG00000003992 AllianceGenome:RGD:1560850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560850
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to contribute to phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Predicted to be involved in several processes, including positive regulation of MAP kinase activity; positive regulation of angiogenesis; and regulation of natural killer cell mediated cytotoxicity. Predicted to be located in membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IB. Orthologous to human PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 31.8), Lung (RPKM 24.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (53702821..53754113)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53203930..53255229)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55085269..55135069)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 like 1 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 Neighboring gene transfer RNA threonine (anticodon UGU) 2 Neighboring gene major facilitator superfamily domain containing 6-like Neighboring gene uncharacterized LOC120095125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Signal amplification between Gbetagamma release and PI3Kgamma-mediated PI(3,4,5)P3 formation monitored by a fluorescent Gbetagamma biosensor protein and repetitive two component total internal reflection/fluorescence redistribution after photobleaching analysis. Tannert A, et al. Biochemistry, 2008 Oct 28. PMID 18831540
    2. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Jiang K, et al. Nat Immunol, 2000 Nov. PMID 11062502
    3. BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling. Liu M, et al. Hypertension, 2022 Dec. PMID 36252138
    4. Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio. Rodríguez-Borlado L, et al. J Immunol, 2003 May 1. PMID 12707323
    5. Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Kurig B, et al. Proc Natl Acad Sci U S A, 2009 Dec 1. PMID 19906996, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling.
      Title: BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IB ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 6
    Names
    p87 phosphoinositide 3-kinase gamma adapter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081444.2 → NP_001074913.2  phosphoinositide 3-kinase regulatory subunit 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LNJ8
      Related
      ENSRNOP00000005405.5, ENSRNOT00000005405.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      53702821..53754113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086581.2 → XP_038942509.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

      Conserved Domains (1) summary
      pfam10486
      Location:104 → 363
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    2. XM_039086580.2 → XP_038942508.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

      Conserved Domains (1) summary
      pfam10486
      Location:104 → 363
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    3. XM_039086575.1 → XP_038942503.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G942, A2TJT9
      Conserved Domains (1) summary
      pfam10486
      Location:104 → 823
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    4. XM_039086574.1 → XP_038942502.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G942, A2TJT9
      Conserved Domains (1) summary
      pfam10486
      Location:104 → 823
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    5. XM_039086576.2 → XP_038942504.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G942, A2TJT9
      Conserved Domains (1) summary
      pfam10486
      Location:104 → 800
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    6. XM_039086578.2 → XP_038942506.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G942
      Conserved Domains (1) summary
      pfam10486
      Location:38 → 716
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    7. XM_039086579.1 → XP_038942507.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G942, A2TJT9, F1LNJ8
      Conserved Domains (1) summary
      pfam10486
      Location:34 → 753
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    8. XM_039086577.2 → XP_038942505.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G942
      Conserved Domains (1) summary
      pfam10486
      Location:38 → 716
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RNA

    1. XR_005489908.2 RNA Sequence

    2. XR_005489906.2 RNA Sequence

    3. XR_005489905.2 RNA Sequence

    4. XR_005489907.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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