Slc44a4 solute carrier family 44, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc44a4provided by RGD
Official Full Name: solute carrier family 44, member 4provided by RGD
Primary source: RGD:1303167
See related: Ensembl:ENSRNOG00000000878 AllianceGenome:RGD:1303167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ng22
Summary: Predicted to enable choline transmembrane transporter activity and thiamine pyrophosphate transmembrane transporter activity. Predicted to be involved in several processes, including acetylcholine biosynthetic process; organic cation transport; and sensory organ development. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to human SLC44A4 (solute carrier family 44 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 251.8), Lung (RPKM 54.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3907737..3923911, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3903099..3919215, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4593389..4609641)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Slc44a4 (e-PCR), detects polymorphism
- UniSTS:547114

D17Ertd710e (e-PCR), detects polymorphism
- UniSTS:167224

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables salt transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine pyrophosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine pyrophosphate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acetylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in acetylcholine secretion	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in choline transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromast hair cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in otolith formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in quaternary ammonium group transport	IEA Inferred from Electronic Annotation more info
involved_in thiamine pyrophosphate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine pyrophosphate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine pyrophosphate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: choline transporter-like protein 4

Names: thiamine pyrophosphate transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.