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    Usp43 ubiquitin specific peptidase 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100147704, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Usp43provided by RGD
    Official Full Name
    ubiquitin specific peptidase 43provided by RGD
    Primary source
    RGD:2303824
    See related
    Ensembl:ENSRNOG00000003785 AllianceGenome:RGD:2303824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and ubiquitin-dependent protein catabolic process. Orthologous to human USP43 (ubiquitin specific peptidase 43). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 12.5), Heart (RPKM 7.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (53047368..53110099, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (52549200..52611168, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (54406980..54467956, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene GSG1-like 2 Neighboring gene dehydrogenase/reductase 7C Neighboring gene uncharacterized LOC100911946 Neighboring gene cilia and flagella associated protein 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 43
    Names
    ubiquitin specific protease 43
    NP_001382953.1
    XP_038940907.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396024.1 → NP_001382953.1  ubiquitin carboxyl-terminal hydrolase 43

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFJ3
      Conserved Domains (1) summary
      COG5560
      Location:77 → 706
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      53047368..53110099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084979.2 → XP_038940907.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X1

      UniProtKB/TrEMBL
      A6HFJ3, D3ZED6
      Related
      ENSRNOP00000062751.2
      Conserved Domains (1) summary
      COG5560
      Location:77 → 711
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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