Dclk3 doublecortin-like kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dclk3provided by RGD
Official Full Name: doublecortin-like kinase 3provided by RGD
Primary source: RGD:1309232
See related: Ensembl:ENSRNOG00000033026 AllianceGenome:RGD:1309232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dcamkl3; RGD1309232
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]
Expression: Biased expression in Kidney (RPKM 135.7), Brain (RPKM 57.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (120279916..120332362)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (111401544..111453999)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (119691567..119744484)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dclk3 is expressed in the pineal gland at levels >16-fold greater than the median expression level in other tissues; in addition, expression exhibits a >10-fold increase at night.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137832 (e-PCR)
- UniSTS:219919

AW529479 (e-PCR)
- UniSTS:261094

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of protein localization to nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase DCLK3

Names: doublecortin and CaM kinase-like 3

NP_001178729.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191800.1 → NP_001178729.1 serine/threonine-protein kinase DCLK3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

F1LWF2

Related

ENSRNOP00000046063.4, ENSRNOT00000044742.6

Conserved Domains (3) summary

smart00220
Location:515 → 772

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl00155
Location:92 → 177

UBQ; Ubiquitin-like proteins

cl21453
Location:514 → 771

PKc_like; Protein Kinases, catalytic domain