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    Coq3 coenzyme Q3 methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29309, updated on 29-Apr-2024

    Summary

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    Official Symbol
    Coq3provided by RGD
    Official Full Name
    coenzyme Q3 methyltransferaseprovided by RGD
    Primary source
    RGD:2380
    See related
    Ensembl:ENSRNOG00000009974 AllianceGenome:RGD:2380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables hexaprenyldihydroxybenzoate methyltransferase activity. Involved in methylation and regulation of ubiquinone biosynthetic process. Located in mitochondrion. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 482.0), Muscle (RPKM 353.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coq3 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40226313..40257383)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (35429567..35460613)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (36024673..36056664)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene PNN interacting serine and arginine rich protein Neighboring gene lysine acetyltransferase 2B, pseudogene 1 Neighboring gene failed axon connections homolog, metaxin like GST domain containing Neighboring gene WEE2 oocyte meiosis inhibiting kinase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a rat cDNA encoding dihydroxypolyprenylbenzoate methyltransferase by functional complementation of a Saccharomyces cerevisiae mutant deficient in ubiquinone biosynthesis. Marbois BN, et al. Gene, 1994 Jan 28. PMID 8125303
    2. Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. Jonassen T, et al. J Biol Chem, 2000 Apr 28. PMID 10777520
    3. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    4. Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. Poon WW, et al. J Biol Chem, 1999 Jul 30. PMID 10419476
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156658

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis O-methyltransferase, mitochondrial
    Names
    2-polyprenyl-6-hydroxyphenol methylase
    2-polyprenyl-6-hydroxyphenyl methylase
    3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
    3-demethylubiquinol 3-O-methyltransferase
    3-demethylubiquinone-9 3-methyltransferase
    DHHB methyltransferase
    DHHB-MT
    DHHB-MTase
    coenzyme Q (ubiquinone)
    coenzyme Q3 homolog, methyltransferase
    dihydroxyhexaprenylbenzoate methyltransferase
    hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
    polyprenyldihydroxybenzoate methyltransferase
    XP_017448690.1
    XP_038965286.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019187.3 → NP_062060.2  ubiquinone biosynthesis O-methyltransferase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      40226313..40257383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593201.3 → XP_017448690.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A0JN24, Q63159, Q642D7
      UniProtKB/TrEMBL
      A6IIF5, Q4G082
      Related
      ENSRNOP00000013384.5
      Conserved Domains (2) summary
      TIGR01983
      Location:96 → 326
      UbiG; ubiquinone biosynthesis O-methyltransferase
      pfam08241
      Location:151 → 250
      Methyltransf_11; Methyltransferase domain

    2. XM_039109358.2 → XP_038965286.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X2

      Conserved Domains (1) summary
      TIGR01983
      Location:20 → 250
      UbiG; ubiquinone biosynthesis O-methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63159.2 GenPept UniProtKB/Swiss-Prot:Q63159

    Gene LinkOut

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