Ackr3 atypical chemokine receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ackr3provided by RGD
Official Full Name: atypical chemokine receptor 3provided by RGD
Primary source: RGD:620601
See related: Ensembl:ENSRNOG00000019622 AllianceGenome:RGD:620601
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rdc1; Cxcr7; Cmkor1
Summary: Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in positive regulation of mesenchymal stem cell migration. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human ACKR3 (atypical chemokine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 129.4), Lung (RPKM 118.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (98247300..98258877)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (90799682..90811246)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (97355881..97367455)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats.
Title: Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats.
Chemokine receptor 7 mediates miRNA-182 to regulate cerebral ischemia/reperfusion injury in rats.
Title: Chemokine receptor 7 mediates miRNA-182 to regulate cerebral ischemia/reperfusion injury in rats.
Gain of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental arthritis via enhancing tissue regeneration and immunomodulation.
Title: Gain of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental arthritis via enhancing tissue regeneration and immunomodulation.
Upregulating CXCR7 accelerates endothelial progenitor cell-mediated endothelial repair by activating Akt/Keap-1/Nrf2 signaling in diabetes mellitus.
Title: Upregulating CXCR7 accelerates endothelial progenitor cell-mediated endothelial repair by activating Akt/Keap-1/Nrf2 signaling in diabetes mellitus.
CXCR7-overexpressing MSCs may markedly facilitate treatment of phosgene-induced ALI (P-ALI) in rats.
Title: Overexpression of CXCR7 promotes mesenchymal stem cells to repair phosgene-induced acute lung injury in rats.
These findings suggest that the manipulation of miR-539-5p/CXCR7 levels may have important therapeutic implications in choroidal neovascularization-associated diseases
Title: miR-539-5p inhibits experimental choroidal neovascularization by targeting CXCR7.
CXCR4 and ACKR3 modulate alpha1-AR reactivity in vascular smooth muscle and regulate hemodynamics in normal and pathological conditions
Title: Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function.
Findings indicate that CXCR-4 and -7 receptors were co-expressed in BMSCs and synergistically promoted BMSC migration.
Title: CXCR-7 receptor promotes SDF-1α-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus.
CXCR4 and CXCR7 form a functional receptor unit in microglial cells, which is up-regulated during activation of microglia both in vitro and in vivo.
Title: CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia.
Grk2 tightly controls CXCR7 signaling in astrocytes by mediating internalization.
Title: Grk2 is an essential regulator of CXCR7 signalling in astrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

UniSTS:240533 (e-PCR)
- UniSTS:240533

AA997721 (e-PCR)
- UniSTS:243390

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-X-C chemokine binding	ISS Inferred from Sequence or Structural Similarity more info
enables C-X-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve development	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mesenchymal stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atypical chemokine receptor 3

Names: C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; G-protein coupled receptor RDC1 homolog; RDC-1; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053352.2 → NP_445804.1 atypical chemokine receptor 3

See identical proteins and their annotated locations for NP_445804.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O89039, Q9JLZ0

Related

ENSRNOP00000091223.1, ENSRNOT00000098919.1

Conserved Domains (1) summary

cd14987
Location:45 → 326

7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

98247300..98258877

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245479.5 → XP_006245541.1 atypical chemokine receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006245541.1

UniProtKB/Swiss-Prot

O89039, Q9JLZ0

Conserved Domains (1) summary

cd14987
Location:45 → 326

7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039084258.2 → XP_038940186.1 atypical chemokine receptor 3 isoform X1

UniProtKB/Swiss-Prot

O89039, Q9JLZ0

Related

ENSRNOP00000086994.1

Conserved Domains (1) summary

cd14987
Location:45 → 326

7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors