Abcg8 ATP binding cassette subfamily G member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcg8provided by RGD
Official Full Name: ATP binding cassette subfamily G member 8provided by RGD
Primary source: RGD:620300
See related: Ensembl:ENSRNOG00000005420 AllianceGenome:RGD:620300
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and cholesterol transfer activity. Involved in several processes, including bile acid signaling pathway; lipid homeostasis; and response to muscle activity. Predicted to be located in apical plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in plasma membrane. Biomarker of cholestasis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 33.9), Kidney (RPKM 2.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (15698448..15717730, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (9945629..9964912, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (7961413..7980708)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In contrast, the marked reduction of hepatic Abcg5/8 observed is an effect of the high sugar content of the diets.
Title: Influence of dietary sugar on cholesterol and bile acid metabolism in the rat: Marked reduction of hepatic Abcg5/8 expression following sucrose ingestion.
Data reveal marked utilization of an Abcg5/Abcg8-independent mechanism for basal biliary cholesterol secretion in rats during lactation, but a dependence on Abcg5/g8 for maximal biliary cholesterol secretion.
Title: ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats.
Hepatic secretion of cholesterol and ABCG5/G8 expression are strongly stimulated in hypophysectomized rats during treatment with thyroid hormone.
Title: Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone.
Intestinal mRNA expression of Abcg5 (-47%) and Abcg8 (-43%) as well as Abcg5 protein contents are reduced in insulin-deficient animals.
Title: Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to ATP binding	ISO Inferred from Sequence Orthology more info
contributes_to ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bile acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intestinal phytosterol absorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sterol transport	ISO Inferred from Sequence Orthology more info
involved_in sterol transport	ISO Inferred from Sequence Orthology more info
involved_in sterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	ISO Inferred from Sequence Orthology more info
part_of ATP-binding cassette (ABC) transporter complex	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family G member 8

Names: ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G (WHITE), member 8; sterolin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130414.2 → NP_569098.2 ATP-binding cassette sub-family G member 8

See identical proteins and their annotated locations for NP_569098.2

Status: PROVISIONAL

Source sequence(s)

AF351785

UniProtKB/Swiss-Prot

P58428, Q8CIQ5, Q923R7

UniProtKB/TrEMBL

A6H9I7

Related

ENSRNOP00000007638.6, ENSRNOT00000007638.8

Conserved Domains (3) summary

cd03234
Location:60 → 295

ABCG_White; White pigment protein homolog of ABCG transporter subfamily

TIGR00955
Location:88 → 662

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

pfam01061
Location:401 → 605

ABC2_membrane; ABC-2 type transporter