Brd1 bromodomain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brd1provided by RGD
Official Full Name: bromodomain containing 1provided by RGD
Primary source: RGD:1311855
See related: Ensembl:ENSRNOG00000004538 AllianceGenome:RGD:1311855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone binding activity. Involved in response to electrical stimulus and response to immobilization stress. Located in dendrite and perikaryon. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 126.8), Adrenal (RPKM 111.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (121653859..121701700, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (119774187..119822032, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (129676119..129724303, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study found a significant 2-fold upregulation of long exon 7 splice variants of the Brd1 gene in hippocampus in both groups of Chronic Restrain Stress rats compared to controls.
Title: The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress.
These findings indicate that regulation of the Brd1 gene is part of the biological response to ECS and that splice variants are induced differentially in different brain regions.
Title: Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat.
These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease.
Title: Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of histone H3-K14 acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bromodomain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108103.3 → NP_001101573.1 bromodomain-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_001101573.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6K7H2

Conserved Domains (5) summary

cd05839
Location:927 → 1042

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

cd15677
Location:214 → 267

PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like
NM_001414946.1 → NP_001401875.1 bromodomain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

D3ZUW8

Related

ENSRNOP00000006034.6, ENSRNOT00000006034.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

121653859..121701700 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079302.2 → XP_038935230.1 bromodomain-containing protein 1 isoform X5

Conserved Domains (2) summary

cd05839
Location:544 → 659

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:52 → 149

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
XM_063263626.1 → XP_063119696.1 bromodomain-containing protein 1 isoform X1
XM_039079301.2 → XP_038935229.1 bromodomain-containing protein 1 isoform X4

Conserved Domains (4) summary

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like
XM_006242197.4 → XP_006242259.1 bromodomain-containing protein 1 isoform X2

Conserved Domains (4) summary

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

cd15677
Location:214 → 267

PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like
XM_039079300.2 → XP_038935228.1 bromodomain-containing protein 1 isoform X3

Conserved Domains (4) summary

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like