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    Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311726, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pcmtd2provided by RGD
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2provided by RGD
    Primary source
    RGD:1305684
    See related
    Ensembl:ENSRNOG00000017404 AllianceGenome:RGD:1305684
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305684
    Summary
    Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in protein methylation. Predicted to be active in cytoplasm. Orthologous to human PCMTD2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 508.9), Brain (RPKM 265.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189337758..189360525)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168960312..168979504)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177351505..177371470)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myelin transcription factor 1 Neighboring gene uncharacterized LOC134486518 Neighboring gene uncharacterized LOC120101836 Neighboring gene zinc finger protein 431-like Neighboring gene RNA polymerase III subunit K Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-isoaspartate O-methyltransferase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107810.1 → NP_001101280.2  protein-L-isoaspartate O-methyltransferase domain-containing protein 2

      See identical proteins and their annotated locations for NP_001101280.2

      Status: PROVISIONAL

      Source sequence(s)
      CH474066
      UniProtKB/TrEMBL
      A6KLV7
      Conserved Domains (1) summary
      pfam01135
      Location:11 → 219
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      189337758..189360525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105160.2 → XP_038961088.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      D3ZY20
      Related
      ENSRNOP00000023989.7
      Conserved Domains (1) summary
      pfam01135
      Location:11 → 193
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    2. XM_063283907.1 → XP_063139977.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KLV7

    3. XM_063283909.1 → XP_063139979.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X3

    4. XM_063283910.1 → XP_063139980.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X4

    5. XM_063283906.1 → XP_063139976.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KLV7

    RNA

    1. XR_010064642.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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