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    Bicdl1 BICD family like cargo adaptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304537, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Bicdl1provided by RGD
    Official Full Name
    BICD family like cargo adaptor 1provided by RGD
    Primary source
    RGD:1310292
    See related
    Ensembl:ENSRNOG00000056955 AllianceGenome:RGD:1310292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc64; RGD1310292
    Summary
    Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and neuron projection development. Predicted to be located in centrosome. Orthologous to human BICDL1 (BICD family like cargo adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 77.2), Brain (RPKM 76.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bicdl1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46537525..46626876)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (40878190..41001152)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46615597..46703287)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547619 Neighboring gene transfer RNA proline (anticodon AGG) 85 Neighboring gene RAB35, member RAS oncogene family Neighboring gene uncharacterized LOC120096002 Neighboring gene GCN1 activator of EIF2AK4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. Schlager MA, et al. EMBO J, 2010 May 19. PMID 20360680, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynactin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to secretory granule transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BICD family-like cargo adapter 1
    Names
    bicaudal D-related protein 1
    coiled-coil domain containing 64

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191667.2 → NP_001178596.1  BICD family-like cargo adapter 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6GEA9, A6J1S4
      Related
      ENSRNOP00000086697.1, ENSRNOT00000119377.1
      Conserved Domains (2) summary
      pfam01665
      Location:100 → 240
      Rota_NSP3; Rotavirus non-structural protein NSP3
      pfam14988
      Location:121 → 297
      DUF4515; Domain of unknown function (DUF4515)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      46537525..46626876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769234.4 → XP_008767456.1  BICD family-like cargo adapter 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY46, A0A0G2KAQ3
      Related
      ENSRNOP00000075484.2
      Conserved Domains (2) summary
      pfam01665
      Location:100 → 240
      Rota_NSP3; Rotavirus non-structural protein NSP3
      pfam14988
      Location:121 → 297
      DUF4515; Domain of unknown function (DUF4515)

    2. XM_063271347.1 → XP_063127417.1  BICD family-like cargo adapter 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY46

    3. XM_063271348.1 → XP_063127418.1  BICD family-like cargo adapter 1 isoform X3

    RNA

    1. XR_010056386.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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