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    Dap3 death associated protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295238, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dap3provided by RGD
    Official Full Name
    death associated protein 3provided by RGD
    Primary source
    RGD:1305339
    See related
    Ensembl:ENSRNOG00000020373 AllianceGenome:RGD:1305339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within apoptotic mitochondrial changes. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be part of mitochondrial small ribosomal subunit. Orthologous to human DAP3 (death associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 101.3), Thymus (RPKM 95.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dap3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176617151..176645293, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174319341..174347489, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188225607..188255324, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 11 Neighboring gene gon-4 like Neighboring gene misato mitochondrial distribution and morphology regulator 1 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene RUN and SH3 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. Kim HR, et al. FASEB J, 2007 Jan. PMID 17135360
    2. The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. Berger T, et al. J Cell Sci, 2000 Oct. PMID 11017876
    3. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. Harada T, et al. Apoptosis, 2010 Oct. PMID 20563667
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of a similar protein in mouse.
      Title: Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS29
    Names
    28S ribosomal protein S29, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011950.2 → NP_001011950.2  small ribosomal subunit protein mS29

      See identical proteins and their annotated locations for NP_001011950.2

      Status: VALIDATED

      Source sequence(s)
      AA964664, BC085878
      UniProtKB/TrEMBL
      A6J6B2, F7EZZ0, Q5U2T0
      Related
      ENSRNOP00000027608.5, ENSRNOT00000027608.8
      Conserved Domains (1) summary
      pfam10236
      Location:97 → 392
      DAP3; Mitochondrial ribosomal death-associated protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176617151..176645293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281611.1 → XP_063137681.1  small ribosomal subunit protein mS29 isoform X3

      UniProtKB/TrEMBL
      A6J6B2, F7EZZ0

    2. XM_039102039.2 → XP_038957967.1  small ribosomal subunit protein mS29 isoform X7

      Conserved Domains (1) summary
      pfam10236
      Location:97 → 299
      DAP3; Mitochondrial ribosomal death-associated protein 3

    3. XM_006232610.5 → XP_006232672.1  small ribosomal subunit protein mS29 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZU0, Q5U2T0
      Related
      ENSRNOP00000084514.1
      Conserved Domains (1) summary
      pfam10236
      Location:97 → 362
      DAP3; Mitochondrial ribosomal death-associated protein 3

    4. XM_039102038.2 → XP_038957966.1  small ribosomal subunit protein mS29 isoform X6

      Conserved Domains (1) summary
      pfam10236
      Location:97 → 279
      DAP3; Mitochondrial ribosomal death-associated protein 3

    5. XM_063281614.1 → XP_063137684.1  small ribosomal subunit protein mS29 isoform X9

    6. XM_063281612.1 → XP_063137682.1  small ribosomal subunit protein mS29 isoform X4

    7. XM_063281613.1 → XP_063137683.1  small ribosomal subunit protein mS29 isoform X8

    8. XM_063281610.1 → XP_063137680.1  small ribosomal subunit protein mS29 isoform X2

    9. XM_063281609.1 → XP_063137679.1  small ribosomal subunit protein mS29 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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