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    Glce glucuronic acid epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363073, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Glceprovided by RGD
    Official Full Name
    glucuronic acid epimeraseprovided by RGD
    Primary source
    RGD:1565253
    See related
    Ensembl:ENSRNOG00000025372 AllianceGenome:RGD:1565253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565253
    Summary
    Predicted to enable calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process and heparin biosynthetic process. Predicted to be active in Golgi apparatus. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 156.8), Thymus (RPKM 146.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glce in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (71441607..71507639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (62546104..62612144, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (67006588..67073723, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 23 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene mitochondrial ribosomal protein S16, pseudogene 1 Neighboring gene sperm equatorial segment protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. Debarnot C, et al. Proc Natl Acad Sci U S A, 2019 Apr 2. PMID 30872481, Free PMC Article
    2. GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling. Li J, et al. Biochem J, 2014 Apr 15. PMID 24499487
    3. Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality. Li JP, et al. J Biol Chem, 2003 Aug 1. PMID 12788935
    4. Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants. Li K, et al. J Biol Chem, 2010 Apr 9. PMID 20118238, Free PMC Article
    5. Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase. Crawford BE, et al. J Biol Chem, 2001 Jun 15. PMID 11279150

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of GLCE in neuritogenesis via SMAD/ID3 signalling was studied via mutagenesis and gene silencing studies.
      Title: GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparosan-N-sulfate-glucuronate 5-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparosan-N-sulfate-glucuronate 5-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heparin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    D-glucuronyl C5-epimerase
    Names
    glucuronyl C5-epimerase
    NP_001414556.1
    XP_038938365.1
    XP_063121830.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427627.1 → NP_001414556.1  D-glucuronyl C5-epimerase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J572, D3ZIK0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      71441607..71507639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265760.1 → XP_063121830.1  D-glucuronyl C5-epimerase isoform X1

      UniProtKB/TrEMBL
      A6J572, D3ZIK0

    2. XM_039082437.2 → XP_038938365.1  D-glucuronyl C5-epimerase isoform X1

      UniProtKB/TrEMBL
      A6J572, D3ZIK0
      Conserved Domains (1) summary
      pfam06662
      Location:417 → 608
      C5-epim_C; D-glucuronyl C5-epimerase C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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