Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bpnt1provided by RGD
Official Full Name: 3'(2'), 5'-bisphosphate nucleotidase 1provided by RGD
Primary source: RGD:621833
See related: Ensembl:ENSRNOG00000002378 AllianceGenome:RGD:621833
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sal3; RnPIP
Summary: Enables 3'(2'),5'-bisphosphate nucleotidase activity; inositol-1,4-bisphosphate 1-phosphatase activity; and magnesium ion binding activity. Predicted to be involved in inositol phosphate dephosphorylation and phosphatidylinositol phosphate biosynthetic process. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 248.0), Adrenal (RPKM 230.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (99397127..99425056)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (96865634..96893506)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (103268045..103292848)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'(2'),5'-bisphosphate nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3'(2'),5'-bisphosphate nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4-bisphosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 3'(2'),5'-bisphosphate nucleotidase 1

Names: 3'-phosphoadenosine 5'-phosphate phosphatase; BPntase 1; PAP phosphatase; PAP-inositol 1,4-phosphatase; PIP; bisphosphate 3'-nucleotidase 1; inositol-polyphosphate 1-phosphatase; scHAL2 analogous 3

NP_741987.1

EC 3.1.3.57

EC 3.1.3.7

XP_006250491.1

EC 3.1.3.57

EC 3.1.3.7

XP_006250492.1

EC 3.1.3.57

EC 3.1.3.7

XP_006250493.1

EC 3.1.3.57

EC 3.1.3.7

XP_038946992.1

EC 3.1.3.57

EC 3.1.3.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_171990.2 → NP_741987.1 3'(2'),5'-bisphosphate nucleotidase 1

See identical proteins and their annotated locations for NP_741987.1

Status: PROVISIONAL

Source sequence(s)

BC085692

UniProtKB/Swiss-Prot

Q9Z1N4

UniProtKB/TrEMBL

A0A8L2Q072, A6JGQ8

Conserved Domains (1) summary

cd01640
Location:11 → 297

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

99397127..99425056

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091064.2 → XP_038946992.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K0V3, A0A8L2Q072, A6JGQ7

Conserved Domains (1) summary

cd01640
Location:11 → 312

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_006250429.4 → XP_006250491.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

See identical proteins and their annotated locations for XP_006250491.1

UniProtKB/TrEMBL

A0A0G2K0V3, A0A8L2Q072, A6JGQ7

Related

ENSRNOP00000071594.1

Conserved Domains (1) summary

cd01640
Location:11 → 312

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_006250431.5 → XP_006250493.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

See identical proteins and their annotated locations for XP_006250493.1

UniProtKB/Swiss-Prot

Q9Z1N4

UniProtKB/TrEMBL

A0A8L2Q072, A6JGQ8

Conserved Domains (1) summary

cd01640
Location:11 → 297

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
XM_006250430.5 → XP_006250492.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

See identical proteins and their annotated locations for XP_006250492.1

UniProtKB/TrEMBL

A0A0G2K0V3, A0A8L2Q072, A6JGQ7

Conserved Domains (1) summary

cd01640
Location:11 → 312

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...