U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Bak1 BCL2-antagonist/killer 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116502, updated on 29-Apr-2024

    Summary

    Official Symbol
    Bak1provided by RGD
    Official Full Name
    BCL2-antagonist/killer 1provided by RGD
    Primary source
    RGD:621635
    See related
    Ensembl:ENSRNOG00000000485 AllianceGenome:RGD:621635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bak
    Summary
    Enables several functions, including chaperone binding activity; heat shock protein binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of release of cytochrome c from mitochondria; and release of cytochrome c from mitochondria. Located in cytosol; membrane; and mitochondrion. Biomarker of intermittent claudication. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 137.4), Spleen (RPKM 106.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bak1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5102334..5111615, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5100480..5109669, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5609620..5618899, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene uncharacterized LOC120098811 Neighboring gene gametogenetin binding protein 1 Neighboring gene inositol 1,4,5-trisphosphate receptor, type 3 Neighboring gene uncharacterized LOC134483859

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC108627

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BH domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables BH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables porin activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables porin activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within B cell negative selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocrine pancreas development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of transmembrane electrochemical gradient ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV-C IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to fungus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to mycotoxin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vagina development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of BAK complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Bcl-2 family protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bcl-2 homologous antagonist/killer

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053812.3NP_446264.1  bcl-2 homologous antagonist/killer

      See identical proteins and their annotated locations for NP_446264.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JJK6, F7EQF3, Q5FVT4, Q9JK59
      Related
      ENSRNOP00000000576.3, ENSRNOT00000000576.6
      Conserved Domains (1) summary
      cd06845
      Location:27181
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5102334..5111615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256101.5XP_006256163.1  bcl-2 homologous antagonist/killer isoform X1

      See identical proteins and their annotated locations for XP_006256163.1

      UniProtKB/TrEMBL
      A6JJK6, F7EQF3, Q5FVT4, Q9JK59
      Conserved Domains (1) summary
      cd06845
      Location:27181
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    2. XM_063278930.1XP_063135000.1  bcl-2 homologous antagonist/killer isoform X2