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    R3hdm2 R3H domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362894, updated on 6-Jun-2024

    Summary

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    Official Symbol
    R3hdm2provided by RGD
    Official Full Name
    R3H domain containing 2provided by RGD
    Primary source
    RGD:1310066
    See related
    Ensembl:ENSRNOG00000007801 AllianceGenome:RGD:1310066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310066
    Summary
    Predicted to enable nucleic acid binding activity. Orthologous to human R3HDM2 (R3H domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 75.9), Kidney (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See R3hdm2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65097685..65225863)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63212519..63340574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70677226..70805255)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093804 Neighboring gene inhibin subunit beta E Neighboring gene inhibin subunit beta C Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 12 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidyl-prolyl cis-trans isomerase D-like Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene NDUFA4, mitochondrial complex associated like 2 Neighboring gene serine hydroxymethyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    R3H domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130557.1 → NP_001124029.1  R3H domain-containing protein 2

      See identical proteins and their annotated locations for NP_001124029.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I5ZKH5, A6HQV5
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam11235
      Location:540 → 734
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam12752
      Location:250 → 303
      SUZ; SUZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65097685..65225863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263810.1 → XP_063119880.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8

    2. XM_063263807.1 → XP_063119877.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8

    3. XM_063263809.1 → XP_063119879.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8

    4. XM_063263808.1 → XP_063119878.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8

    5. XM_039079498.2 → XP_038935426.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    6. XM_039079496.2 → XP_038935424.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    7. XM_063263819.1 → XP_063119889.1  R3H domain-containing protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    8. XM_039079497.2 → XP_038935425.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    9. XM_017594931.3 → XP_017450420.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    10. XM_063263820.1 → XP_063119890.1  R3H domain-containing protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZKH5

    11. XM_006241483.5 → XP_006241545.1  R3H domain-containing protein 2 isoform X21

      See identical proteins and their annotated locations for XP_006241545.1

      UniProtKB/TrEMBL
      A0A8I5ZKH5, A6HQV5
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam11235
      Location:540 → 734
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam12752
      Location:250 → 303
      SUZ; SUZ domain

    12. XM_063263824.1 → XP_063119894.1  R3H domain-containing protein 2 isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZKH5

    13. XM_063263815.1 → XP_063119885.1  R3H domain-containing protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    14. XM_063263821.1 → XP_063119891.1  R3H domain-containing protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZKH5

    15. XM_008765413.2 → XP_008763635.1  R3H domain-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_008763635.1

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    16. XM_063263817.1 → XP_063119887.1  R3H domain-containing protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K4E8, G3V9G7

    17. XM_063263811.1 → XP_063119881.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8

    18. XM_039079499.2 → XP_038935427.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    19. XM_039079500.2 → XP_038935428.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    20. XM_063263812.1 → XP_063119882.1  R3H domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K4E8

    21. XM_039079511.2 → XP_038935439.2  R3H domain-containing protein 2 isoform X28

    22. XM_063263825.1 → XP_063119895.1  R3H domain-containing protein 2 isoform X26

    23. XM_063263814.1 → XP_063119884.1  R3H domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A0G2K4E8

    24. XM_063263806.1 → XP_063119876.1  R3H domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4E8

    25. XM_063263813.1 → XP_063119883.1  R3H domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    26. XM_039079506.2 → XP_038935434.2  R3H domain-containing protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    27. XM_039079501.2 → XP_038935429.2  R3H domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKH5

    28. XM_039079504.2 → XP_038935432.2  R3H domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K4E8

    29. XM_063263822.1 → XP_063119892.1  R3H domain-containing protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A0G2K4E8

    30. XM_063263818.1 → XP_063119888.1  R3H domain-containing protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    31. XM_017594936.3 → XP_017450425.2  R3H domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4E8

    32. XM_039079507.2 → XP_038935435.2  R3H domain-containing protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZKH5

    33. XM_017594940.3 → XP_017450429.2  R3H domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    34. XM_063263823.1 → XP_063119893.1  R3H domain-containing protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    35. XM_039079502.2 → XP_038935430.2  R3H domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZKH5

    36. XM_039079508.2 → XP_038935436.2  R3H domain-containing protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    37. XM_039079505.2 → XP_038935433.2  R3H domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K4E8

    38. XM_017594943.3 → XP_017450432.2  R3H domain-containing protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    39. XM_017594935.3 → XP_017450424.1  R3H domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    40. XM_063263816.1 → XP_063119886.1  R3H domain-containing protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZLX2

    41. XM_006241472.3 → XP_006241534.1  R3H domain-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006241534.1

      UniProtKB/TrEMBL
      A0A0G2K4E8
      Conserved Domains (3) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:468 → 801
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:250 → 302
      SUZ; SUZ domain

    42. XM_039079509.1 → XP_038935437.1  R3H domain-containing protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I5ZLX2
      Conserved Domains (2) summary
      cd02642
      Location:168 → 229
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:427 → 717
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    43. XM_039079510.1 → XP_038935438.1  R3H domain-containing protein 2 isoform X27

      Conserved Domains (2) summary
      pfam09606
      Location:198 → 531
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:2 → 32
      SUZ; SUZ domain

    44. XM_063263826.1 → XP_063119896.1  R3H domain-containing protein 2 isoform X29

    45. XM_063263828.1 → XP_063119898.1  R3H domain-containing protein 2 isoform X30

    46. XM_063263827.1 → XP_063119897.1  R3H domain-containing protein 2 isoform X29

    Nucleotide Protein Strain
    Heading Accession and Version

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