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    Ap5m1 adaptor-related protein complex 5, mu 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 74385, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ap5m1provided by MGI
    Official Full Name
    adaptor-related protein complex 5, mu 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1921635
    See related
    Ensembl:ENSMUSG00000036291 AllianceGenome:MGI:1921635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mu5; Mudeng; 4932432K03Rik
    Summary
    Predicted to be involved in endosomal transport. Predicted to act upstream of or within protein transport. Predicted to be located in membrane. Predicted to be part of AP-type membrane coat adaptor complex. Predicted to be active in cytosol; late endosome; and lysosome. Orthologous to human AP5M1 (adaptor related protein complex 5 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.2), limb E14.5 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C1; 14 25.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49303869..49331681)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49066408..49094114)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36024 Neighboring gene STARR-seq mESC enhancer starr_36624 Neighboring gene predicted gene, 23470 Neighboring gene exocyst complex component 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:49686153-49686414 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel protein, MUDENG, induces cell death in cytotoxic T cells. Lee MR, et al. Biochem Biophys Res Commun, 2008 Jun 6. PMID 18395520
    2. The fifth adaptor protein complex. Hirst J, et al. PLoS Biol, 2011 Oct. PMID 22022230, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-5 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of AP-type membrane coat adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-type membrane coat adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-5 complex subunit mu-1
    Names
    MHD domain-containing death-inducing protein
    MU-2/AP1M2 domain containing, death-inducing
    adapter-related protein complex 5 mu subunit
    adapter-related protein complex 5 subunit mu-1
    adaptor-related protein complex 5 subunit mu-1
    mu-2-related death-inducing protein
    muD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360070.1 → NP_001346999.1  AP-5 complex subunit mu-1

      Status: VALIDATED

      Source sequence(s)
      AK016540, AK030928, CT025618
      Consensus CDS
      CCDS26995.1
      UniProtKB/Swiss-Prot
      Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
      UniProtKB/TrEMBL
      A0A0R4J0K9
      Conserved Domains (1) summary
      cd09256
      Location:196 → 482
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    2. NM_144535.5 → NP_653118.3  AP-5 complex subunit mu-1

      See identical proteins and their annotated locations for NP_653118.3

      Status: VALIDATED

      Source sequence(s)
      AK016540, AK030928, AK051372, AK164148
      Consensus CDS
      CCDS26995.1
      UniProtKB/Swiss-Prot
      Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
      UniProtKB/TrEMBL
      A0A0R4J0K9
      Related
      ENSMUSP00000046536.5, ENSMUST00000037473.6
      Conserved Domains (1) summary
      cd09256
      Location:196 → 482
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      49303869..49331681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245212.4 → XP_011243514.1  AP-5 complex subunit mu-1 isoform X1

      See identical proteins and their annotated locations for XP_011243514.1

      UniProtKB/Swiss-Prot
      Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
      UniProtKB/TrEMBL
      A0A0R4J0K9
      Conserved Domains (1) summary
      cd09256
      Location:196 → 482
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    2. XM_006519623.5 → XP_006519686.1  AP-5 complex subunit mu-1 isoform X1

      See identical proteins and their annotated locations for XP_006519686.1

      UniProtKB/Swiss-Prot
      Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
      UniProtKB/TrEMBL
      A0A0R4J0K9
      Conserved Domains (1) summary
      cd09256
      Location:196 → 482
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    3. XM_006519626.5 → XP_006519689.1  AP-5 complex subunit mu-1 isoform X3

      Conserved Domains (1) summary
      cd09256
      Location:1 → 263
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    4. XM_036158881.1 → XP_036014774.1  AP-5 complex subunit mu-1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
      Conserved Domains (1) summary
      cd09256
      Location:196 → 406
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    5. XM_006519624.5 → XP_006519687.1  AP-5 complex subunit mu-1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
      Conserved Domains (1) summary
      cd09256
      Location:196 → 406
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    6. XM_036158882.1 → XP_036014775.1  AP-5 complex subunit mu-1 isoform X3

      Conserved Domains (1) summary
      cd09256
      Location:1 → 263
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    RNA

    1. XR_003950905.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ63.2 GenPept UniProtKB/Swiss-Prot:Q8BJ63

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