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    Mlf2 myeloid leukemia factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312709, updated on 25-Apr-2024

    Summary

    Official Symbol
    Mlf2provided by RGD
    Official Full Name
    myeloid leukemia factor 2provided by RGD
    Primary source
    RGD:1306294
    See related
    Ensembl:ENSRNOG00000016589 AllianceGenome:RGD:1306294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in cytoplasm and nucleus. Orthologous to human MLF2 (myeloid leukemia factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 604.2), Muscle (RPKM 485.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mlf2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159425542..159430584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157739651..157744325)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157452578..157457254)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene lymphocyte activating 3 Neighboring gene parathymosin Neighboring gene U6 spliceosomal RNA Neighboring gene COP9 signalosome subunit 7A Neighboring gene uncharacterized LOC120102387

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107889.1NP_001101359.1  myeloid leukemia factor 2

      See identical proteins and their annotated locations for NP_001101359.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6ILN3, D3ZPN3
      Related
      ENSRNOP00000074799.2, ENSRNOT00000088622.2
      Conserved Domains (1) summary
      pfam10248
      Location:26198
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159425542..159430584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237363.5XP_006237425.1  myeloid leukemia factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006237425.1

      UniProtKB/TrEMBL
      A6ILN3, D3ZPN3
      Related
      ENSRNOP00000022467.5
      Conserved Domains (1) summary
      pfam10248
      Location:26198
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
    2. XM_006237364.5XP_006237426.1  myeloid leukemia factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006237426.1

      UniProtKB/TrEMBL
      A6ILN3, D3ZPN3
      Conserved Domains (1) summary
      pfam10248
      Location:26198
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein