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    Zfp46 zinc finger protein 46 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298558, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zfp46provided by RGD
    Official Full Name
    zinc finger protein 46provided by RGD
    Primary source
    RGD:1310584
    See related
    Ensembl:ENSRNOG00000070170 AllianceGenome:RGD:1310584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF436 (zinc finger protein 436). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 87.1), Muscle (RPKM 80.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp46 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153802887..153813388)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148519398..148529903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154644099..154655132)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A3 Neighboring gene immunoglobulin heavy chain 6 like 1 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene uncharacterized LOC120103181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 436

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106691.1 → NP_001100161.1  zinc finger protein 436 isoform 2

      See identical proteins and their annotated locations for NP_001100161.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ITA8
      Conserved Domains (3) summary
      COG5048
      Location:86 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:271 → 296
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001399075.1 → NP_001386004.1  zinc finger protein 436 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Conserved Domains (3) summary
      smart00349
      Location:14 → 82
      KRAB; krueppel associated box
      COG5048
      Location:163 → 470
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196 → 216
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153802887..153813388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239152.5 → XP_006239214.1  zinc finger protein 436 isoform X2

      See identical proteins and their annotated locations for XP_006239214.1

      UniProtKB/TrEMBL
      A0A8I6GFA5, A6ITA7
      Conserved Domains (3) summary
      smart00349
      Location:1 → 64
      KRAB; krueppel associated box
      COG5048
      Location:145 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_008764219.4 → XP_008762441.1  zinc finger protein 436 isoform X2

      See identical proteins and their annotated locations for XP_008762441.1

      UniProtKB/TrEMBL
      A0A8I6GFA5, A6ITA7
      Conserved Domains (3) summary
      smart00349
      Location:1 → 64
      KRAB; krueppel associated box
      COG5048
      Location:145 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_039109642.2 → XP_038965570.1  zinc finger protein 436 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GFA5, A6ITA7
      Conserved Domains (3) summary
      smart00349
      Location:1 → 64
      KRAB; krueppel associated box
      COG5048
      Location:145 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_008764218.4 → XP_008762440.1  zinc finger protein 436 isoform X1

      See identical proteins and their annotated locations for XP_008762440.1

      Conserved Domains (3) summary
      smart00349
      Location:14 → 82
      KRAB; krueppel associated box
      COG5048
      Location:163 → 470
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196 → 216
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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