FCGRT Fc gamma receptor and transporter [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCGRTprovided by HGNC
Official Full Name: Fc gamma receptor and transporterprovided by HGNC
Primary source: HGNC:HGNC:3621
See related: Ensembl:ENSG00000104870 MIM:601437; AllianceGenome:HGNC:3621
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FCRN; FcgammaRn; alpha-chain
Summary: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression: Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (49512661..49526428)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (52512666..52526423)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (50015918..50029685)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
Title: Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
The therapeutic age of the neonatal Fc receptor.
Title: The therapeutic age of the neonatal Fc receptor.
Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Title: Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Human IgE does not bind to human FcRn.
Title: Human IgE does not bind to human FcRn.
An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
Title: An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
Title: Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
Research progress on neonatal Fc receptor and its application.
Title: Research progress on neonatal Fc receptor and its application.
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
Title: Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
Demonstration of fibrinogen-FcRn binding at acidic pH by means of Fluorescence Correlation Spectroscopy.
Title: Demonstration of fibrinogen-FcRn binding at acidic pH by means of Fluorescence Correlation Spectroscopy.
V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor.
Title: V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of hematological and biochemical traits in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-12954 (e-PCR)
- UniSTS:20850

RH103715 (e-PCR)
- UniSTS:98040

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables IgG binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-2-microglobulin binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables peptide antigen binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor	NAS Non-traceable Author Statement more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: IgG receptor FcRn large subunit p51

Names: Fc fragment of IgG receptor and transporter; Fc fragment of IgG, receptor, transporter, alpha; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; heavy chain of the major histocompatibility complex class I-like Fc receptor; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; neonatal Fc receptor; neonatal Fc-receptor for Ig; transmembrane alpha chain of the neonatal receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136019.3 → NP_001129491.1 IgG receptor FcRn large subunit p51 isoform 1 precursor

See identical proteins and their annotated locations for NP_001129491.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AC010619, BC091487, BE245284

Consensus CDS

CCDS12770.1

UniProtKB/Swiss-Prot

P55899, Q5HYM5, Q9HBV7, Q9NZ19

UniProtKB/TrEMBL

A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1

Related

ENSP00000221466.4, ENST00000221466.10

Conserved Domains (2) summary

cd21011
Location:198 → 290

IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

cl08246
Location:25 → 197

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_001411064.1 → NP_001397993.1 IgG receptor FcRn large subunit p51 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR, compared to variant 1 and skips an internal exon. It encodes a shorter protein (2), compared to isoform 1.

Source sequence(s)

AC010619

Consensus CDS

CCDS92663.1

UniProtKB/TrEMBL

M0R0A9

Related

ENSP00000471118.1, ENST00000596975.5
NM_004107.5 → NP_004098.1 IgG receptor FcRn large subunit p51 isoform 1 precursor

See identical proteins and their annotated locations for NP_004098.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

BC008734, BE245284

Consensus CDS

CCDS12770.1

UniProtKB/Swiss-Prot

P55899, Q5HYM5, Q9HBV7, Q9NZ19

UniProtKB/TrEMBL

A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1

Related

ENSP00000410798.2, ENST00000426395.7

Conserved Domains (2) summary

cd21011
Location:198 → 290

IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

cl08246
Location:25 → 197

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

49512661..49526428

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438411.1 → XP_047294367.1 IgG receptor FcRn large subunit p51 isoform X3
XM_047438408.1 → XP_047294364.1 IgG receptor FcRn large subunit p51 isoform X1
XM_047438410.1 → XP_047294366.1 IgG receptor FcRn large subunit p51 isoform X2
XM_047438412.1 → XP_047294368.1 IgG receptor FcRn large subunit p51 isoform X4

Related

ENSP00000469933.1, ENST00000600273.5

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

52512666..52526423

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320202.1 → XP_054176177.1 IgG receptor FcRn large subunit p51 isoform X3
XM_054320200.1 → XP_054176175.1 IgG receptor FcRn large subunit p51 isoform X1
XM_054320201.1 → XP_054176176.1 IgG receptor FcRn large subunit p51 isoform X2
XM_054320203.1 → XP_054176178.1 IgG receptor FcRn large subunit p51 isoform X4
XM_054320199.1 → XP_054176174.1 IgG receptor FcRn large subunit p51 isoform X5

UniProtKB/Swiss-Prot

P55899, Q5HYM5, Q9HBV7, Q9NZ19

UniProtKB/TrEMBL

A0A024QZI2