Atp5mc3 ATP synthase membrane subunit c locus 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5mc3provided by MGI
Official Full Name: ATP synthase membrane subunit c locus 3provided by MGI
Primary source: MGI:MGI:2442035
See related: Ensembl:ENSMUSG00000018770 AllianceGenome:MGI:2442035
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atp5g3; 6030447M23
Summary: The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]
Expression: Ubiquitous expression in heart adult (RPKM 896.5), kidney adult (RPKM 502.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 43.9 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (73738791..73742793, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (73908447..73912464, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We obtained correlations between Atp5g3 and alcoholism- and obesity-relevant phenotypes.
Title: Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ligand-gated channel activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, proton-transporting domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase F(0) complex subunit C3, mitochondrial

Names: ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P3; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9); ATPase protein 9; ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301721.1 → NP_001288650.1 ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

See identical proteins and their annotated locations for NP_001288650.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AI851824, AL844581, CF104340, CX208968

Consensus CDS

CCDS16136.1

UniProtKB/Swiss-Prot

P56384

UniProtKB/TrEMBL

Q14BC2

Related

ENSMUSP00000107627.2, ENSMUST00000111996.8

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional
NM_001301722.1 → NP_001288651.1 ATP synthase F(0) complex subunit C3, mitochondrial isoform b precursor

See identical proteins and their annotated locations for NP_001288651.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AI851824, AL844581, AW554443, CF104340

Conserved Domains (1) summary

cl00466
Location:67 → 89

ATP-synt_C; ATP synthase subunit C
NM_175015.3 → NP_778180.1 ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

See identical proteins and their annotated locations for NP_778180.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AI851824, AL844581, CF104340

Consensus CDS

CCDS16136.1

UniProtKB/Swiss-Prot

P56384

UniProtKB/TrEMBL

Q14BC2

Related

ENSMUSP00000018914.3, ENSMUST00000018914.3

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

73738791..73742793 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250178.2 → XP_030106038.1 ATP synthase F(0) complex subunit C3, mitochondrial isoform X1

UniProtKB/Swiss-Prot

P56384

UniProtKB/TrEMBL

Q14BC2

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional
XM_030250179.2 → XP_030106039.1 ATP synthase F(0) complex subunit C3, mitochondrial isoform X2

Conserved Domains (1) summary

cl00466
Location:67 → 104

ATP-synt_C; ATP synthase subunit C