Dbi diazepam binding inhibitor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dbiprovided by MGI
Official Full Name: diazepam binding inhibitorprovided by MGI
Primary source: MGI:MGI:94865
See related: Ensembl:ENSMUSG00000026385 AllianceGenome:MGI:94865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP; Acbp; ACBD1; endozepine
Summary: Predicted to enable benzodiazepine receptor binding activity; identical protein binding activity; and long-chain fatty acyl-CoA binding activity. Acts upstream of or within several processes, including behavioral fear response; lateral ventricle development; and long-term synaptic potentiation. Located in mitochondrion. Is expressed in brain; cerebral cortex subventricular zone; cerebral cortex ventricular layer; early conceptus; and neocortex. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 440.8), subcutaneous fat pad adult (RPKM 390.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (120041010..120048826, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (120113280..120121096, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice.
Title: Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice.
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis.
Title: ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis.
Acbp is essential for decidualization during early pregnancy in mice.
Title: Acbp is essential for decidualization during early pregnancy in mice.
Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI).
Title: Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI).
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
Title: Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
Data suggest that diazepam binding inhibitor selectively influences certain forms of spatial learning and memory.
Title: Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice.
These findings uncover ACBP as an ARC gliopeptide playing a key role in energy balance control and exerting strong anorectic effects via the central melanocortin system.
Title: The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system.
DBI-/- mice demonstrated an enhancement of inhibition in CA1 pyramidal cells, but displayed an attenuation of inhibition in dentate gyrus granule cells. Presynaptic release probability remained constant in both genotypes, and DBI-/- mice did not differ from DBI+/+ mice in their response to BZ-binding site agonism or antagonism.
Title: Subregion-Specific Impacts of Genetic Loss of Diazepam Binding Inhibitor on Synaptic Inhibition in the Murine Hippocampus.
DBI is expressed in stem cells in all neurogenic niches of the postnatal brain. DBI regulates the balance between preserving the stem cell pool and neurogenesis. Specifically, DBI dampens GABA activity in stem cells, thereby sustaining the proproliferative effect of physical exercise and enriched environment.
Title: Diazepam Binding Inhibitor Promotes Stem Cell Expansion Controlling Environment-Dependent Neurogenesis.
ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activity by 7-fold. ACBP binds very-long-chain acyl-CoA esters, which is required for its ability to stimulate CerS activity.
Title: Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables benzodiazepine receptor binding	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral ventricle development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within learning or memory	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of protein-lipid complex	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-CoA-binding protein

Names: diazepam binding inhibitor, splice form 1b

NP_001033088.1

EC 3.4.17.3

NP_031856.1

EC 3.4.17.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037999.2 → NP_001033088.1 acyl-CoA-binding protein isoform 1

See identical proteins and their annotated locations for NP_001033088.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC139867

Consensus CDS

CCDS15231.1

UniProtKB/TrEMBL

F6ZM12, Q4VWZ5

Related

ENSMUSP00000114705.3, ENSMUST00000151708.3

Conserved Domains (1) summary

cd00435
Location:52 → 134

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_007830.4 → NP_031856.1 acyl-CoA-binding protein isoform 2

See identical proteins and their annotated locations for NP_031856.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AK020692, AV001592, CJ183794

Consensus CDS

CCDS15230.1

UniProtKB/Swiss-Prot

P31786

UniProtKB/TrEMBL

Q3ULV8, Q548W7

Related

ENSMUSP00000027634.7, ENSMUST00000027634.13

Conserved Domains (1) summary

cd00435
Location:2 → 86

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...