Apoc2 apolipoprotein C2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apoc2provided by RGD
Official Full Name: apolipoprotein C2provided by RGD
Primary source: RGD:2135
See related: Ensembl:ENSRNOG00000018402 AllianceGenome:RGD:2135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Apo-CII; ApoC-II; RGD1560725
Summary: Predicted to enable several functions, including identical protein binding activity; lipase activator activity; and phospholipase binding activity. Involved in lipoprotein transport and response to xenobiotic stimulus. Predicted to be located in extracellular space. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 6966.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88457397..88462365, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79329429..79334397, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80589023..80593991, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein C-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.