Plce1 phospholipase C, epsilon 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plce1provided by MGI
Official Full Name: phospholipase C, epsilon 1provided by MGI
Primary source: MGI:MGI:1921305
See related: Ensembl:ENSMUSG00000024998 AllianceGenome:MGI:1921305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plce; mKIAA1516; PLCepsilon; 4933403A21Rik
Summary: Predicted to enable phosphatidylinositol phospholipase C activity and small GTPase binding activity. Predicted to be involved in several processes, including diacylglycerol biosynthetic process; intracellular signal transduction; and regulation of signal transduction. Predicted to act upstream of or within lipid catabolic process and signal transduction. Predicted to be located in cytosol; lamellipodium; and plasma membrane. Is expressed in several structures, including facial bone primordium; heart; liver; nervous system; and thymus. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 5.0), limb E14.5 (RPKM 3.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 33.16 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (38469438..38773549)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (38481034..38785105)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phospholipase C epsilon-1 (PLCE1) mediates macrophage activation and protection against tuberculosis.
Title: Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.
Phospholipase C-epsilon defines a PACAP-stimulated pathway for secretion in the chromaffin cell.
Title: Phospholipase C-ε defines a PACAP-stimulated pathway for secretion in the chromaffin cell.
Phospholipase Cepsilon insufficiency causes ascending aortic aneurysm and dissection.
Title: Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
Results suggest that phospholipase C epsilon 1 (PLCepsilon1) is a potential regulator of tumor-infiltrating lymphocytes, functioning, at least in part, at the level of T cell trafficking and recruitment.
Title: PLCε1 suppresses tumor growth by regulating murine T cell mobilization.
Plce1 deficiency in mice predisposes to glomerular damage secondary to hypertensive insults.
Title: Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency.
The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2
Title: Genome-Wide Association Mapping for Female Infertility in Inbred Mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 receptors. Among the six isoforms of phospholipase C (PLC; PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta, PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Title: The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.
study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury
Title: Phospholipase Cε deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice.
PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis.
Title: Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.
Title: Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plce1 (e-PCR), detects polymorphism
- UniSTS:265425

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Names: PLC-epsilon-1; phosphoinositide phospholipase C-epsilon-1

NP_062534.2

EC 3.1.4.11

XP_006527457.1

EC 3.1.4.11

XP_006527458.1

EC 3.1.4.11

XP_011245682.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019588.2 → NP_062534.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

See identical proteins and their annotated locations for NP_062534.2

Status: VALIDATED

Source sequence(s)

AB076247, AC158905, AK122521, AK162236, BF466343, CD803532, CF537630, CN535034

Consensus CDS

CCDS37973.1

UniProtKB/Swiss-Prot

B9EHS1, E9Q5G0, Q3TS68, Q80TC4, Q8BZF3, Q8K4S1, Q9JKM2

UniProtKB/TrEMBL

S4R1Q8

Related

ENSMUSP00000130604.2, ENSMUST00000169713.9

Conserved Domains (7) summary

cd00275
Location:1848 → 1964

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1372 → 1813

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PRK12355
Location:221 → 283

PRK12355; type-F conjugative transfer system mating-pair stabilization protein TraN

cd16203
Location:1179 → 1359

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cd01780
Location:2114 → 2216

RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cd17229
Location:1987 → 2094

RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cl02485
Location:528 → 826

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

38469438..38773549

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527394.4 → XP_006527457.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

See identical proteins and their annotated locations for XP_006527457.1

UniProtKB/TrEMBL

S4R1Q8

Conserved Domains (7) summary

cd00275
Location:1864 → 1980

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1388 → 1829

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PRK12355
Location:221 → 283

PRK12355; type-F conjugative transfer system mating-pair stabilization protein TraN

cd16203
Location:1195 → 1375

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cd01780
Location:2130 → 2232

RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cd17229
Location:2003 → 2110

RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cl02485
Location:528 → 826

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_011247380.3 → XP_011245682.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

See identical proteins and their annotated locations for XP_011245682.1

UniProtKB/Swiss-Prot

B9EHS1, E9Q5G0, Q3TS68, Q80TC4, Q8BZF3, Q8K4S1, Q9JKM2

UniProtKB/TrEMBL

S4R1Q8

Related

ENSMUSP00000138360.2, ENSMUST00000182481.8

Conserved Domains (7) summary

cd00275
Location:1848 → 1964

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1372 → 1813

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PRK12355
Location:221 → 283

PRK12355; type-F conjugative transfer system mating-pair stabilization protein TraN

cd16203
Location:1179 → 1359

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cd01780
Location:2114 → 2216

RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cd17229
Location:1987 → 2094

RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cl02485
Location:528 → 826

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_006527395.5 → XP_006527458.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/TrEMBL

B7ZNH9, S4R1Q8

Conserved Domains (6) summary

cd00275
Location:1483 → 1599

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1007 → 1448

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

cd16203
Location:814 → 994

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cd01780
Location:1749 → 1851

RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cd17229
Location:1622 → 1729

RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cl02485
Location:147 → 445

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...