Pvalb parvalbumin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pvalbprovided by RGD
Official Full Name: parvalbuminprovided by RGD
Primary source: RGD:3457
See related: AllianceGenome:RGD:3457
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pva; PALB1
Summary: Enables calcium ion binding activity and identical protein binding activity. Involved in cochlea development. Located in several cellular components, including cuticular plate; neuronal cell body; and stereocilium. Part of protein-containing complex. Orthologous to human PVALB (parvalbumin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 21291.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111653820..111668469, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109772939..109787954, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119428657..119443674, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocampal parvalbumin and perineuronal nets: Possible involvement in anxiety-like behavior in rats.
Title: Hippocampal parvalbumin and perineuronal nets: Possible involvement in anxiety-like behavior in rats.
Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats.
Title: Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats.
Dendritic inhibition differentially controls input-output transformations in parvalbumin-expressing interneurons (PVIs) and granule cells (GCs) of the dentate gyrus.
Title: Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells.
Chronic mild stress induced a specific decrease of parvalbumin expression in the dorsal hippocampus, an effect normalized by lurasidone treatment. Interestingly, the regulation of parvalbumin levels was correlated to the modulation of the antioxidant master regulator NRF2 and its chaperon protein KEAP1, which were also modulated by pharmacological intervention.
Title: Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone.
These results demonstrate that amino acids of the cluster I of beta parvalbumin provide more essential contribution to the maintenance of structural and functional properties of the protein in comparison with the residues of the cluster II.
Title: Comprehensive analysis of the roles of 'black' and 'gray' clusters in structure and function of rat β-parvalbumin.
The results of this study indicated that there are significantly more PV-positive neurons in the left basolateral amygdala compared to the right, with a significant difference specifically in the posterior subdivision.
Title: Hemispheric differences in the number of parvalbumin-positive neurons in subdivisions of the rat basolateral amygdala complex.
Peripubertal diazepam attenuated the decrease of parvalbumin in the ventral hippocampus of methylazoxymethanol acetate rats.
Title: Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.
NOX2 activation in the hippocampus, at least in part, contributes to oxidative stress and neuroinflammation, which further results in PV interneuron loss and consequent Post-traumatic stress disorder.
Title: NOX2 Mediated-Parvalbumin Interneuron Loss Might Contribute to Anxiety-Like and Enhanced Fear Learning Behavior in a Rat Model of Post-Traumatic Stress Disorder.
enriched environment might prevent the juvenile hypoxia-induced developmental loss of PV cells in the prefrontal cortex and attenuate the neurobehavioral alterations through inhibition of NOX2-derived oxidative stress.
Title: Environmental Enrichment Prevent the Juvenile Hypoxia-Induced Developmental Loss of Parvalbumin-Immunoreactive Cells in the Prefrontal Cortex and Neurobehavioral Alterations Through Inhibition of NADPH Oxidase-2-Derived Oxidative Stress.
Residues 49, 50, 57-60 were replaced with their counterparts from rat beta-parvalbumin. E59D, alone or with the other mutations, confers Ca2+ specificity on the CD site.
Title: Site-directed mutagenesis of rat α-parvalbumin: replacement of canonical CD-site residues with their non-consensus counterparts from rat β-parvalbumin.

Submit: New GeneRIF Correction See all GeneRIFs (51)

General gene information

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Markers

RH135405 (e-PCR)
- UniSTS:218682

RH94476 (e-PCR)
- UniSTS:119724

Pva (e-PCR), detects polymorphism
- UniSTS:144307

X59382 (e-PCR)
- UniSTS:163560

D22S1030 (e-PCR)
- UniSTS:6907

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in inhibitory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cuticular plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	HDA more info	PubMed

General protein information

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Preferred Names: parvalbumin alpha

Names: Parvalbumin (calcium binding protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022499.2 → NP_071944.1 parvalbumin alpha

See identical proteins and their annotated locations for NP_071944.1

Status: PROVISIONAL

Source sequence(s)

BC126090

UniProtKB/Swiss-Prot

A0JN21, P02625

UniProtKB/TrEMBL

A6HSI5

Conserved Domains (2) summary

cd00051
Location:43 → 108

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:44 → 107

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111653820..111668469 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241929.5 → XP_006241991.1 parvalbumin alpha isoform X1

See identical proteins and their annotated locations for XP_006241991.1

UniProtKB/Swiss-Prot

A0JN21, P02625

UniProtKB/TrEMBL

A6HSI5

Conserved Domains (2) summary

cd00051
Location:43 → 108

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:44 → 107

EF-hand_7; EF-hand domain pair