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    Targ3 Terminal ADP-ribose protein glycohydrolase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740205, updated on 29-Dec-2023

    Summary

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    Official Symbol
    Targ3provided by FlyBase
    Official Full Name
    Terminal ADP-ribose protein glycohydrolase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0085290
    Locus tag
    Dmel_CG34261
    See related
    AllianceGenome:FB:FBgn0085290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34261; Dmel\CG34261; dTarg3
    Summary
    Predicted to enable ADP-ribosylglutamate hydrolase activity and purine nucleoside binding activity. Predicted to be involved in peptidyl-glutamate ADP-deribosylation and purine nucleoside metabolic process. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    78C2-78C2; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21196831..21197738)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21189931..21190838)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin Neighboring gene Terminal ADP-ribose protein glycohydrolase 1 Neighboring gene Terminal ADP-ribose protein glycohydrolase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
    2. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables purine nucleoside binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-glutamate ADP-deribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    terminal ADP-ribose protein glycohydrolase 3
    Names
    CG34261-PB
    Targ3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21196831..21197738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104186.3 → NP_001097656.1  terminal ADP-ribose protein glycohydrolase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNW5
      Conserved Domains (1) summary
      cd02901
      Location:7 → 133
      Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNW5 A8JNW5

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