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    Adck1 aarF domain containing kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 72113, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Adck1provided by MGI
    Official Full Name
    aarF domain containing kinase 1provided by MGI
    Primary source
    MGI:MGI:1919363
    See related
    Ensembl:ENSMUSG00000021044 AllianceGenome:MGI:1919363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610005A10Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in lipid homeostasis; mitochondrion organization; and regulation of mitochondrion organization. Predicted to act upstream of or within phosphorylation. Located in mitochondrion. Orthologous to human ADCK1 (aarF domain containing kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 9.4), adrenal adult (RPKM 8.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adck1 in Genome Data Viewer
    Location:
    12 D2- D3; 12 42.55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (88327264..88428496)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (88360494..88461726)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3200001D21 gene Neighboring gene RIKEN cDNA 4930473H19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:89667228-89667411 Neighboring gene STARR-seq mESC enhancer starr_32906 Neighboring gene CDK5 and Abl enzyme substrate 2 pseudogene Neighboring gene ubiquitin specific peptidase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32907 Neighboring gene STARR-seq mESC enhancer starr_32908 Neighboring gene uncharacterized protein C1orf103 homolog Neighboring gene STARR-seq mESC enhancer starr_32909 Neighboring gene STARR-seq mESC enhancer starr_32910 Neighboring gene STARR-seq mESC enhancer starr_32911 Neighboring gene neurexin III Neighboring gene STARR-seq mESC enhancer starr_32912 Neighboring gene VISTA enhancer mm296 Neighboring gene predicted gene, 40537

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antibody immunodiversity: a study on the marked specificity difference between two anti-yeast iso-1 cytochrome c monoclonal antibodies whose epitopes are closely related. Rizzo P, et al. J Protein Chem, 1999 Jul. PMID 10524770
    2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aarF domain-containing protein kinase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277296.1 → NP_001264225.1  aarF domain-containing protein kinase 1 isoform a

      See identical proteins and their annotated locations for NP_001264225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longest isoform (a).
      Source sequence(s)
      AK011310, AK050868, BB042684, BB868931, BY242507
      Consensus CDS
      CCDS26087.1
      UniProtKB/Swiss-Prot
      Q3UKJ2, Q9D0L4
      Related
      ENSMUSP00000152821.2, ENSMUST00000222695.2
      Conserved Domains (1) summary
      cd13969
      Location:117 → 369
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    2. NM_001277297.1 → NP_001264226.1  aarF domain-containing protein kinase 1 isoform a

      See identical proteins and their annotated locations for NP_001264226.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longest isoform (a).
      Source sequence(s)
      AK011310, AK050868, BB042684, BY242507
      Consensus CDS
      CCDS26087.1
      UniProtKB/Swiss-Prot
      Q3UKJ2, Q9D0L4
      Related
      ENSMUSP00000098724.3, ENSMUST00000101165.9
      Conserved Domains (1) summary
      cd13969
      Location:117 → 369
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    3. NM_001361598.1 → NP_001348527.1  aarF domain-containing protein kinase 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      CT030260, CT485612
      Conserved Domains (1) summary
      cd13969
      Location:84 → 311
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    4. NM_001361599.1 → NP_001348528.1  aarF domain-containing protein kinase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      CT030260, CT485612
      Conserved Domains (1) summary
      cd13969
      Location:73 → 248
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    5. NM_001361600.1 → NP_001348529.1  aarF domain-containing protein kinase 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      BB850741, CT030260, CT485612
      Conserved Domains (1) summary
      cd13969
      Location:1 → 243
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    6. NM_001361601.1 → NP_001348530.1  aarF domain-containing protein kinase 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      BY198896, CT030260, CT485612
      Conserved Domains (1) summary
      cd13969
      Location:15 → 190
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    7. NM_028105.4 → NP_082381.1  aarF domain-containing protein kinase 1 isoform a

      See identical proteins and their annotated locations for NP_082381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longest isoform (a).
      Source sequence(s)
      AK050868, BB042684, BY291967
      Consensus CDS
      CCDS26087.1
      UniProtKB/Swiss-Prot
      Q3UKJ2, Q9D0L4
      Related
      ENSMUSP00000127254.2, ENSMUST00000166940.3
      Conserved Domains (1) summary
      cd13969
      Location:117 → 369
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      88327264..88428496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516246.4 → XP_006516309.1  aarF domain-containing protein kinase 1 isoform X4

      Conserved Domains (1) summary
      cd13969
      Location:74 → 301
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    2. XM_030246934.2 → XP_030102794.1  aarF domain-containing protein kinase 1 isoform X1

      Conserved Domains (1) summary
      cd13969
      Location:127 → 379
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    3. XM_006516251.4 → XP_006516314.1  aarF domain-containing protein kinase 1 isoform X8

      See identical proteins and their annotated locations for XP_006516314.1

      Conserved Domains (1) summary
      cd13969
      Location:1 → 243
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    4. XM_006516245.5 → XP_006516308.1  aarF domain-containing protein kinase 1 isoform X2

      Conserved Domains (1) summary
      cd13969
      Location:76 → 328
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    5. XM_006516248.5 → XP_006516311.1  aarF domain-containing protein kinase 1 isoform X7

      Conserved Domains (1) summary
      cd13969
      Location:66 → 295
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    6. XM_030246938.2 → XP_030102798.1  aarF domain-containing protein kinase 1 isoform X4

      Conserved Domains (1) summary
      cd13969
      Location:74 → 301
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    7. XM_030246935.1 → XP_030102795.1  aarF domain-containing protein kinase 1 isoform X1

      Conserved Domains (1) summary
      cd13969
      Location:127 → 379
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    8. XM_030246933.2 → XP_030102793.1  aarF domain-containing protein kinase 1 isoform X1

      Conserved Domains (1) summary
      cd13969
      Location:127 → 379
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    9. XM_030246937.2 → XP_030102797.1  aarF domain-containing protein kinase 1 isoform X3

      Conserved Domains (1) summary
      cd13969
      Location:84 → 311
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    10. XM_030246939.2 → XP_030102799.1  aarF domain-containing protein kinase 1 isoform X8

      Conserved Domains (1) summary
      cd13969
      Location:1 → 243
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    11. XM_030246936.2 → XP_030102796.1  aarF domain-containing protein kinase 1 isoform X2

      Conserved Domains (1) summary
      cd13969
      Location:76 → 328
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    12. XM_006516252.5 → XP_006516315.1  aarF domain-containing protein kinase 1 isoform X8

      See identical proteins and their annotated locations for XP_006516315.1

      Conserved Domains (1) summary
      cd13969
      Location:1 → 243
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    13. XM_030246940.2 → XP_030102800.1  aarF domain-containing protein kinase 1 isoform X9

      Conserved Domains (1) summary
      cd13969
      Location:1 → 177
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    14. XM_036157619.1 → XP_036013512.1  aarF domain-containing protein kinase 1 isoform X5

      Conserved Domains (1) summary
      cd13969
      Location:45 → 297
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    15. XM_036157620.1 → XP_036013513.1  aarF domain-containing protein kinase 1 isoform X6

      Related
      ENSMUST00000223538.2
      Conserved Domains (1) summary
      cd13969
      Location:68 → 297
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0L4.1 GenPept UniProtKB/Swiss-Prot:Q9D0L4

    Gene LinkOut

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