TBPH TAR DNA-binding protein-43 homolog [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TBPHprovided by FlyBase
Official Full Name: TAR DNA-binding protein-43 homologprovided by FlyBase
Primary source: FLYBASE:FBgn0025790
Locus tag: Dmel_CG10327
See related: AllianceGenome:FB:FBgn0025790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10327; Dmel\CG10327; dmTDP43; dtar; dTBPH; dTDP; dTDP-43; tbph; Tbph; TDP-43; TDP43; TDPH
Summary: Enables GU repeat RNA binding activity and single-stranded DNA binding activity. Involved in several processes, including adult walking behavior; regulation of synapse organization; and synapse organization. Located in H zone; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryonic/larval nervous system; extended germ band embryo; gastrula embryo; and muscle system. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; frontotemporal dementia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 60A4-60A5; 2-105 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23859067..23862593, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19746590..19750116, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization.
Title: cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization.
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.
Title: Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.
TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
Title: TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance.
Title: TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance.
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.
Title: Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.
A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy.
Title: A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy.
C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
Title: C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
Title: TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Title: CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.
Title: Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GU repeat RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular steroid hormone receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of intracellular steroid hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular steroid hormone receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in H zone	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TAR DNA-binding protein-43 homolog

Names: CG10327-PA; CG10327-PB; CG10327-PC; CG10327-PD; CG10327-PE; CG10327-PF; TAR DNA binding protein; TBPH-PA; TBPH-PB; TBPH-PC; TBPH-PD; TBPH-PE; TBPH-PF; Tar DNA binding protein homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23859067..23862593 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134318.3 → NP_599145.1 TAR DNA-binding protein-43 homolog, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599145.1

Status: REVIEWED

UniProtKB/TrEMBL

O97468, Q8SXP8, Q9W1I1

Related

FBpp0088568

Conserved Domains (2) summary

cd12321
Location:108 → 184

RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

cd12322
Location:192 → 261

RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
NM_058052.4 → NP_477400.1 TAR DNA-binding protein-43 homolog, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477400.1

Status: REVIEWED

UniProtKB/TrEMBL

O97468, Q8SXP8, Q9W1I1

Related

FBpp0088567

Conserved Domains (2) summary

cd12321
Location:108 → 184

RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

cd12322
Location:192 → 261

RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
NM_001169810.2 → NP_001163281.1 TAR DNA-binding protein-43 homolog, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163281.1

Status: REVIEWED

UniProtKB/TrEMBL

O97468, Q8SXP8, Q9W1I1

Conserved Domains (2) summary

cd12321
Location:108 → 184

RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

cd12322
Location:192 → 261

RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
NM_058051.4 → NP_477399.1 TAR DNA-binding protein-43 homolog, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477399.1

Status: REVIEWED

UniProtKB/TrEMBL

O97469, Q9W1I0

Related

FBpp0088569

Conserved Domains (2) summary

cd12321
Location:108 → 184

RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

cd12322
Location:192 → 261

RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
NM_166628.3 → NP_726373.1 TAR DNA-binding protein-43 homolog, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726373.1

Status: REVIEWED

UniProtKB/TrEMBL

O97468, Q8SXP8, Q9W1I1

Related

FBpp0088570

Conserved Domains (2) summary

cd12321
Location:108 → 184

RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

cd12322
Location:192 → 261

RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
NM_001169809.2 → NP_001163280.1 TAR DNA-binding protein-43 homolog, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163280.1

Status: REVIEWED

UniProtKB/TrEMBL

O97468, Q8SXP8, Q9W1I1

Conserved Domains (2) summary

cd12321
Location:108 → 184

RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

cd12322
Location:192 → 261

RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins