Socs44A Suppressor of Cytokine Signaling at 44A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Socs44Aprovided by FlyBase
Official Full Name: Suppressor of Cytokine Signaling at 44Aprovided by FlyBase
Primary source: FLYBASE:FBgn0033266
Locus tag: Dmel_CG2160
See related: AllianceGenome:FB:FBgn0033266
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2160; Dmel\CG2160; dmSocs44A; SOCS; socs42A; socs44A; Socs44a; SOCS44A; Socs44E
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Involved in negative regulation of receptor signaling pathway via JAK-STAT and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval trachea; and oocyte. Human ortholog(s) of this gene implicated in atopic dermatitis 4; malaria; reproductive organ cancer (multiple); tuberculosis; and urinary bladder cancer. Orthologous to several human genes including CISH (cytokine inducible SH2 containing protein) and SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 44B3-44B3; 2-58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8127575..8129476)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4015080..4016981)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: suppressor of cytokine signaling at 44A

Names: CG2160-PA; Socs44A-PA; suppressor of cytokine signaling at 44E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8127575..8129476

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078935.3 → NP_523659.1 suppressor of cytokine signaling at 44A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523659.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVF1

Related

FBpp0087862

Conserved Domains (2) summary

cd09923
Location:188 → 266

SH2_SOCS_family; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) family

cl02533
Location:293 → 333

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...