MRC2 mannose receptor C type 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MRC2provided by HGNC
Official Full Name: mannose receptor C type 2provided by HGNC
Primary source: HGNC:HGNC:16875
See related: Ensembl:ENSG00000011028 MIM:612264; AllianceGenome:HGNC:16875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD280; UPARAP; CLEC13E; ENDO180
Summary: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Expression: Ubiquitous expression in gall bladder (RPKM 26.1), ovary (RPKM 24.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q23.2

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (62627670..62693597)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (63497612..63563512)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (60705031..60770958)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.
Title: The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.
MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy.
Title: MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy.
Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer.
Title: Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer.
These results indicate that a substance secreted from UVB-exposed keratinocytes regulates Endo180 expression and that IL-1alpha may play an important role in the maintenance of Endo180.
Title: Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.
In lung tissue from idiopathic pulmonary fibrosis patients, a strong up-regulation of uPARAP was observed in fibroblasts adjacent to regions with SP-D secretion.
Title: Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.
Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2).
Title: Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.
results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family
Title: Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.
A model of the ligand-binding region of uPARAP was obtained by molecular replacement.
Title: Expression and crystallographic studies of the ligand-binding region of the human endocytic collagen receptor uPARAP.
The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript.
Title: The mRNA expression of soluble urokinase plasminogen activator surface receptor in human adipose tissue is positively correlated with body mass index.
Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma
Title: Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells	PubMed
	env	Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay	PubMed
	env	Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells	PubMed
	env	HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin	PubMed
	env	HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes	PubMed
Tat	tat	HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor	PubMed
	tat	HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80967 (e-PCR)
- UniSTS:91252

RH12891 (e-PCR)
- UniSTS:69023

MRC2_7204 (e-PCR)
- UniSTS:466340

MARC_26180-26181:1030714398:1 (e-PCR)
- UniSTS:268973

D17S1283 (e-PCR)
- UniSTS:18605

RH47836 (e-PCR)
- UniSTS:19895

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	HDA more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	HDA more info	PubMed
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: C-type mannose receptor 2

Names: C-type lectin domain family 13 member E; UPAR-associated protein; endocytic receptor (macrophage mannose receptor family); endocytic receptor 180; macrophage mannose receptor 2; urokinase-type plasminogen activator receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033955.1 RefSeqGene

Range

5270..71197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006039.5 → NP_006030.2 C-type mannose receptor 2 precursor

See identical proteins and their annotated locations for NP_006030.2

Status: REVIEWED

Source sequence(s)

AI458446, BC032763, BC146647, BC153884

Consensus CDS

CCDS11634.1

UniProtKB/Swiss-Prot

A6H8K4, D3DU08, Q7LGE7, Q9UBG0, Q9Y5P9

Related

ENSP00000307513.5, ENST00000303375.10

Conserved Domains (5) summary

smart00059
Location:180 → 228

FN2; Fibronectin type 2 domain

cd00037
Location:247 → 361

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:382 → 505

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:46 → 161

RICIN; Ricin-type beta-trefoil

cd00161
Location:43 → 127

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

62627670..62693597

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047437208.1 → XP_047293164.1 C-type mannose receptor 2 isoform X2
XM_011525543.2 → XP_011523845.1 C-type mannose receptor 2 isoform X1

Conserved Domains (5) summary

smart00059
Location:180 → 228

FN2; Fibronectin type 2 domain

cd00037
Location:247 → 361

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:382 → 505

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:46 → 161

RICIN; Ricin-type beta-trefoil

cd00161
Location:43 → 127

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...