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    RIB3 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852098, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RIB3
    Gene description
    3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3
    Primary source
    SGD:S000002895
    Locus tag
    YDR487C
    See related
    AllianceGenome:SGD:S000002895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity. Involved in aerobic respiration and riboflavin biosynthetic process. Located in cytosol and mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1428354..1428980, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vps72p Neighboring gene Vps60p Neighboring gene dynein intermediate chain Neighboring gene DNA replication protein SLD5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration. Jin C, et al. J Biol Chem, 2003 Apr 25. PMID 12595523
    2. Thiol redox proteomics identifies differential targets of cytosolic and mitochondrial glutaredoxin-2 isoforms in Saccharomyces cerevisiae. Reversible S-glutathionylation of DHBP synthase (RIB3). McDonagh B, et al. J Proteomics, 2011 Oct 19. PMID 21565288
    3. Genetical classification of riboflavineless mutants of Saccharomyces cerevisiae. Oltmanns O, et al. Antonie Van Leeuwenhoek, 1969 Jun. PMID 5312045
    4. Biochemical and genetic classification of riboflavine deficient mutants of Saccharomyces cerevisiae. Oltmanns O, et al. Mol Gen Genet, 1969. PMID 5366000
    5. The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae. Spitzner A, et al. Genetics, 2008 Dec. PMID 18940788, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. One target protein, Rib3p, which has as yet an undefined function in respiration, was confirmed to have its Cys56 reversibly S-glutathionylated in vitro in a Grx2p dependent process.
      Title: Thiol redox proteomics identifies differential targets of cytosolic and mitochondrial glutaredoxin-2 isoforms in Saccharomyces cerevisiae. Reversible S-glutathionylation of DHBP synthase (RIB3).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3
    NP_010775.1
    • 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1428354..1428980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180795.1 → NP_010775.1  TPA: 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTB0, Q99258
      UniProtKB/TrEMBL
      A0A6A5Q2D7, A6ZZ76, B3LFH9, B5VH15, C7GKS5, C8Z645, G2WBL6, N1P7M6
      Conserved Domains (1) summary
      pfam00926
      Location:6 → 205
      DHBP_synthase; 3,4-dihydroxy-2-butanone 4-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99258.1

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