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    PTK1 putative serine/threonine protein kinase PTK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853635, updated on 17-May-2024

    Summary

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    Gene symbol
    PTK1
    Gene description
    putative serine/threonine protein kinase PTK1
    Primary source
    FungiDB:YKL198C
    Locus tag
    YKL198C
    See related
    SGD:S000001681; AllianceGenome:SGD:S000001681; VEuPathDB:YKL198C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KKT8; POT1; STK1; YKL199C; YKT9
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in spermine transport. Orthologous to human TSSK6 (testis specific serine kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PTK1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (68232..70220, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol kinase-related protein kinase TOR2 Neighboring gene Mnn4p Neighboring gene AAA family ATPase peroxin 1 Neighboring gene tRNA-Asn

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Kakinuma Y, et al. Biochem Biophys Res Commun, 1995 Nov 22. PMID 7488221
    2. The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae. Kaouass M, et al. Mol Cell Biol, 1997 Jun. PMID 9154797, Free PMC Article
    3. A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Nozaki T, et al. Biochem Biophys Res Commun, 1996 Nov 12. PMID 8920934
    4. β-Oxidation and autophagy are critical energy providers during acute glucose depletion in Saccharomyces cerevisiae. Weber CA, et al. Proc Natl Acad Sci U S A, 2020 Jun 2. PMID 32430326, Free PMC Article
    5. Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis. Erez O, et al. Mol Cell Biol, 2001 Jan. PMID 11113192, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase PTK1
    NP_012723.3
    • Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      68232..70220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179764.2 → NP_012723.3  TPA: putative serine/threonine protein kinase PTK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012723.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX02, P36002, P36045, Q06941
      UniProtKB/TrEMBL
      A0A8H4BXR1, A7A088, B5VLW6
      Conserved Domains (1) summary
      cl21453
      Location:202 → 503
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36002.3

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